Factors associated with COVID-19 vaccine uptake in people with kidney disease: an OpenSAFELY cohort study.
Factors associated with COVID-19 vaccine uptake in people with kidney disease: an OpenSAFELY cohort study.
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DOI：
10.1136/bmjopen-2022-066164
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发表时间：
2023-01-31
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
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作者：
研究英格兰肾病患者接种COVID-19疫苗的相关因素。使用OpenSAFELY-TPP平台进行的回顾性队列研究，经英国NHS批准。使用TPP软件，来自英国2400万GP的个人水平常规临床数据。初级保健数据与截至2022年8月31日的COVID-19疫苗记录直接关联，并通过英国肾脏登记处（UKRR）与肾脏替代治疗（RRT）状态直接关联。根据估计肾小球滤过率（eGFR）降低或纳入UKRR的证据，确定了在COVID-19疫苗推广开始时患有3-5期慢性肾病（CKD）或接受RRT的成人队列。特定剂量疫苗随时间的覆盖率由二零二零年十二月一日至二零二二年八月三十一日厘定。通过考克斯比例风险模型探索与接受3剂或4剂疫苗系列相关的个体水平因素。纳入992 205例3-5期CKD或接受RRT的患者。截至2022年8月31日，在有一种或多种合格适应症的个体中，第1、2和3剂次的累计疫苗覆盖率分别为97. 5%、97. 0%和93. 9%，第4剂次的覆盖率为81. 9%。延迟接种3剂疫苗与年龄较小、少数族裔、社会剥夺和严重精神疾病有关--这种相关性在CKD严重程度亚组、透析患者和肾移植受者中是一致的。4剂摄入也观察到类似的相关性。尽管英格兰肾病患者的初级疫苗和加强剂接种率很高，但在临床和人口统计学群体中，疫苗接种的主要差异仍然存在，4剂接种率不理想。需要采取有针对性的干预措施，以确定本研究中确定的接种不足亚组中疫苗接种的障碍。
To characterise factors associated with COVID-19 vaccine uptake among people with kidney disease in England. Retrospective cohort study using the OpenSAFELY-TPP platform, performed with the approval of NHS England. Individual-level routine clinical data from 24 million people across GPs in England using TPP software. Primary care data were linked directly with COVID-19 vaccine records up to 31 August 2022 and with renal replacement therapy (RRT) status via the UK Renal Registry (UKRR). A cohort of adults with stage 3–5 chronic kidney disease (CKD) or receiving RRT at the start of the COVID-19 vaccine roll-out was identified based on evidence of reduced estimated glomerular filtration rate (eGFR) or inclusion in the UKRR. Dose-specific vaccine coverage over time was determined from 1 December 2020 to 31 August 2022. Individual-level factors associated with receipt of a 3-dose or 4-dose vaccine series were explored via Cox proportional hazards models. 992 205 people with stage 3–5 CKD or receiving RRT were included. Cumulative vaccine coverage as of 31 August 2022 was 97.5%, 97.0% and 93.9% for doses 1, 2 and 3, respectively, and 81.9% for dose 4 among individuals with one or more indications for eligibility. Delayed 3-dose vaccine uptake was associated with younger age, minority ethnicity, social deprivation and severe mental illness—associations that were consistent across CKD severity subgroups, dialysis patients and kidney transplant recipients. Similar associations were observed for 4-dose uptake. Although high primary vaccine and booster dose coverage has been achieved among people with kidney disease in England, key disparities in vaccine uptake remain across clinical and demographic groups and 4-dose coverage is suboptimal. Targeted interventions are needed to identify barriers to vaccine uptake among under-vaccinated subgroups identified in the present study.
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影响因子：
19.6
作者：
Ng, Jia H.;Hirsch, Jamie S.;Fishbane, Steven
通讯作者：
Fishbane, Steven
DOI：
10.3399/bjgp.2021.0376
发表时间：
2022-01
期刊：
The British journal of general practice : the journal of the Royal College of General Practitioners
影响因子：
--
作者：
Curtis HJ;Inglesby P;Morton CE;MacKenna B;Green A;Hulme W;Walker AJ;Morley J;Mehrkar A;Bacon S;Hickman G;Bates C;Croker R;Evans D;Ward T;Cockburn J;Davy S;Bhaskaran K;Schultze A;Rentsch CT;Williamson EJ;Rowan A;Fisher L;McDonald HI;Tomlinson L;Mathur R;Drysdale H;Eggo RM;Wing K;Wong AY;Forbes H;Parry J;Hester F;Harper S;O'Hanlon S;Eavis A;Jarvis R;Avramov D;Griffiths P;Fowles A;Parkes N;Douglas IJ;Evans SJ;Smeeth L;Goldacre B;(The OpenSAFELY Collaborative)
通讯作者：
(The OpenSAFELY Collaborative)
DOI：
10.1056/nejmoa2119451
发表时间：
2022-04-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Andrews N;Stowe J;Kirsebom F;Toffa S;Rickeard T;Gallagher E;Gower C;Kall M;Groves N;O'Connell AM;Simons D;Blomquist PB;Zaidi A;Nash S;Iwani Binti Abdul Aziz N;Thelwall S;Dabrera G;Myers R;Amirthalingam G;Gharbia S;Barrett JC;Elson R;Ladhani SN;Ferguson N;Zambon M;Campbell CNJ;Brown K;Hopkins S;Chand M;Ramsay M;Lopez Bernal J
通讯作者：
Lopez Bernal J
英格兰和威尔士的初级保健医生如何管理慢性肾脏疾病的人？国家慢性肾脏疾病审核的结果。
DOI：
10.1093/ndt/gfx280
发表时间：
2018-08-01
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
Kim LG;Cleary F;Wheeler DC;Caplin B;Nitsch D;Hull SA;UK National Chronic Kidney Disease Audit
通讯作者：
UK National Chronic Kidney Disease Audit
影响因子：
39.2
作者：
Levey AS;Stevens LA;Schmid CH;Zhang YL;Castro AF 3rd;Feldman HI;Kusek JW;Eggers P;Van Lente F;Greene T;Coresh J;CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
通讯作者：
CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)