The efficacy of a lysine-based dendritic hydrogel does not differ from those of commercially available tissue sealants and adhesives: an ex vivo study.
The efficacy of a lysine-based dendritic hydrogel does not differ from those of commercially available tissue sealants and adhesives: an ex vivo study.
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DOI：
10.1186/s12891-015-0573-7
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发表时间：
2015-05-13
影响因子：
2.3
通讯作者：
Nazarian A
中科院分区：
文献类型：
--
作者：
Villa-Camacho JC;Ghobril C;Anez-Bustillos L;Grinstaff MW;Rodríguez EK;Nazarian A
Hemostatic agents, tissue adhesives and sealants may contribute to a reduction in hemorrhage-associated morbidity and mortality. Towards this end, we have recently developed a lysine-based dendritic hydrogel (PEG-LysNH2) that can potentially be used in the management of severe trauma and/or intraoperative bleeding. As a first step in demonstrating the potential utility of this approach, our objective was to ascertain the ability of the PEG-LysNH2 to adhere to and seal injured tissues, as well as to maintain the seal under physiological conditions. The efficacy of the PEG-LysNH2 in sealing injured tissues was evaluated using an ex-vivo pressure testing system. A 2.5 mm incision was made on intact ex-vivo tissues and then sealed with the PEG-LysNH2. Application of the PEG-LysNH2 was followed by 1) step-wise pressure increase to a maximum of 250 mmHg and 2) fluctuating pressures, between 100–180 mmHg with a rate of 3 Hz, over a 24-hour period. The performance of the PEG-LysNH2 was compared to those of commercially available sealants and adhesives. During gradual pressure increase, mean pressures at 30 seconds (P30) ranged between 206.36 - 220.17 mmHg for the sealants, and they were greater than control and suture groups (p < 0.01 and p = 0.013, respectively). Additionally, all products held under fluctuating pressures: mean pressures ranged between 135.20 - 160.09 mmHg, and there were no differences observed between groups (p = 0.96). The efficacy of the PEG-LysNH2 was significantly superior to conventional injury repair methods (sutures) and did not differ from those of commercially available products when sealing small incisions.
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影响因子：
2.9
作者：
Spotnitz, William D.;Burks, Sandra
通讯作者：
Burks, Sandra
影响因子：
1.2
作者：
Alam, HB;Burris, D;Rhee, P
通讯作者：
Rhee, P
影响因子：
3.2
作者：
van Zutphen, LFM;van der Valk, JBF
通讯作者：
van der Valk, JBF
DOI：
10.1007/8415_2010_48
发表时间：
2011-01-01
期刊：
ACTIVE IMPLANTS AND SCAFFOLDS FOR TISSUE REGENERATION
影响因子：
--
作者：
Mizrahi, Boaz;Weldon, Christopher;Kohane, Daniel S.
通讯作者：
Kohane, Daniel S.
影响因子：
1.9
作者：
Kheirabadi, Bijan S.;Sieber, Jennifer;Holcomb, John B.
通讯作者：
Holcomb, John B.