On correlated sources of uncertainty in four dimensional computed tomography data sets.
On correlated sources of uncertainty in four dimensional computed tomography data sets.
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DOI：
10.1177/153303461000900309
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发表时间：
2010-06
影响因子：
2.8
通讯作者：
Tome W
中科院分区：
文献类型：
--
作者：
Ehler E;Tome W
这项工作的目的是估计一个给定的四维计算机断层扫描（4D-CT）成像模式固有的不确定性的程度，并测试的相互作用的调查因素（即对象位移，速度和运动的周期）时，确定对象的运动坐标，运动包络，和共形性，它可以定义在一个基于时间的数据系列。利用一维运动平台上的低密度泡沫中的四个玻璃球组成的运动体模，研究了运动轨迹中不确定性因素的相互作用，可用于在最佳4D-CT成像环境中比较轨迹定义、运动包络定义和保形性。运动平台允许高度定义的运动轨迹，其可以作为与4D-CT数据集中观察到的运动进行比较的基础事实。采集9种不同运动模式的4D-CT数据集。进行多因素方差分析（ANOVA），其中考虑的因素是体模最大速度、对象体积和用于描绘高密度对象的图像强度。没有发现统计学意义的三个因素的相互作用的定义的运动轨迹，运动包络，或骰子相似系数（DSC）的一致性。对于DSC，发现两个因素的相互作用具有统计学显著性：1）对象体积和用于描绘的HU阈值的相互作用，以及2）对象速度和对象体积的相互作用。此外，一个统计上显着的单因素直接成正比的最大速度和平均跟踪误差之间观察。在这项工作中，多个因素影响的不确定性，在4D数据集已被认为是一些统计上显着的两个因素的相互作用已经确定。因此，建议对4D成像模式中的误差和不确定性进行详细评价，以评估各种不确定性因素之间相互作用的临床意义。
The purpose of this work is to estimate the degree of uncertainty inherent to a given four dimensional computed tomography (4D-CT) imaging modality and to test for interaction of the investigated factors (i.e. object displacement, velocity, and the period of motion) when determining the object motion coordinates, motion envelope, and the confomality in which it can be defined within a time based data series. A motion phantom consisting of four glass spheres imbedded in low density foam on a one dimensional moving platform was used to investigate the interaction of uncertainty factors in motion trajectory that could be used in comparison of trajectory definition, motion envelope definition and conformality in an optimal 4D-CT imaging environment. The motion platform allowed for a highly defined motion trajectory that could be as the ground truth in the comparison with observed motion in 4D-CT data sets. 4D-CT data sets were acquired for 9 different motion patterns. Multifactor analysis of variance (ANOVA) was performed where the factors considered were the phantom maximum velocity, object volume, and the image intensity used to delineate the high density objects. No statistical significance was found for three factor interaction for definition of the motion trajectory, motion envelope, or Dice Similarity Coefficient (DSC) conformality. Two factor interactions were found to be statistically significant for the DSC for the interactions of 1) object volume and the HU threshold used for delineation and 2) the object velocity and object volume. Moreover, a statistically significant single factor direct proportionality was observed between the maximum velocity and the mean tracking error. In this work multiple factors impacting on the uncertainty in 4D data sets have been considered and some statistically significant two-factor interactions have been identified. Therefore, the detailed evaluation of errors and uncertainties in 4D imaging modalities is recommended in order to assess the clinical implications of interaction among the various uncertainty factors.
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影响因子：
3.8
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/j.ijrobp.2007.12.025
发表时间：
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DOI：
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发表时间：
2008-12-01
影响因子：
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作者：
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通讯作者：
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作者：
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