Longitudinal association of magnetic resonance elastography-associated liver stiffness with complications and mortality.
Longitudinal association of magnetic resonance elastography-associated liver stiffness with complications and mortality.
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DOI：
10.1111/apt.16745
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发表时间：
2022-02
影响因子：
7.6
通讯作者：
Izumi, Namiki
中科院分区：
文献类型：
--
作者：
Higuchi, Mayu;Tamaki, Nobuharu;Kurosaki, Masayuki;Inada, Kento;Kirino, Sakura;Yamashita, Koji;Hayakawa, Yuka;Osawa, Leona;Takaura, Kenta;Maeyashiki, Chiaki;Kaneko, Shun;Yasui, Yutaka;Takahashi, Yuka;Tsuchiya, Kaoru;Nakanishi, Hiroyuki;Itakura, Jun;Loomba, Rohit;Enomoto, Nobuyuki;Izumi, Namiki
磁共振弹性成像（MRE）对肝纤维化的诊断准确率最高；然而，MRE 相关的肝脏硬度与肝脏和肝外并发症以及死亡率之间的关系仍不清楚。在这项研究中，我们调查了 MRE 相关的肝脏硬度与并发症和死亡率之间的纵向关联。这项回顾性研究纳入了 2373 名连续患有慢性肝病的患者。所有患者均接受标准护理，并且每 1-6 个月评估一次并发症的发生情况。新诊断的肝细胞癌（HCC）、失代偿、主要不良心血管事件（MACE）、肝外癌和死亡分别为 99、117、73、77 和 170 名患者。在多变量分析中，HCC、失代偿、MACE、肝外癌和死亡率的调整后风险比 (aHR)（95% 置信区间 [CI]）分别为 1.28 (1.2-1.4)、1.34 (1.3-1.4)、0.96 (0.9-1.1)、1.00 (0.9-1.1) 和 1.17 (1.1-1.2)，每增加 1 kPa 肝脏僵硬。同样，肝硬化患者的 HCC、失代偿、MACE、肝外癌和死亡率的 aHR (95% CI) 分别为 4.20 (2.2-8.2)、67.5 (9.2-492)、0.83 (0.4-1.7)、0.90 (0.5-1.7) 和 2.90 (1.6-5.4)。 (>4.7 kPa) 与那些具有最小 纤维化（<3 kPa）。 MRE 相关的肝脏硬度增加与 HCC、失代偿和死亡率的风险增加相关，且呈剂量依赖性，但与 MACE 或肝外癌无关，这表明 MRE 在肝脏相关事件和死亡率中发挥着重要作用；然而，需要进一步研究来探讨其在 MACE 和肝外癌中的作用。
Magnetic resonance elastography (MRE) has the highest diagnostic accuracy for liver fibrosis; however, the association between MRE-associated liver stiffness and the development of hepatic and extrahepatic complications as well as mortality remains unclear. In this study, we investigated the longitudinal association between MRE-associated liver stiffness and complications and mortality. This retrospective study included 2373 consecutive patients with chronic liver disease. All patients received standard of care and the development of complications was assessed every 1-6 months. Newly diagnosed hepatocellular carcinoma (HCC), decompensation, major adverse cardiovascular events (MACE), extrahepatic cancer and death were observed in 99, 117, 73, 77 and 170 patients respectively. In multivariable analysis, the adjusted hazard ratios (aHR) (95% confidence interval [CI]) for HCC, decompensation, MACE, extrahepatic cancer and mortality were 1.28 (1.2-1.4), 1.34 (1.3-1.4), 0.96 (0.9-1.1), 1.00 (0.9-1.1) and 1.17 (1.1-1.2), respectively, with each 1-kPa increase in liver stiffness. Similarly, the aHR (95% CI) for HCC, decompensation, MACE, extrahepatic cancer and mortality were 4.20 (2.2-8.2), 67.5 (9.2-492), 0.83 (0.4-1.7), 0.90 (0.5-1.7) and 2.90 (1.6-5.4), respectively, in patients with cirrhosis (>4.7 kPa) compared to those with minimal fibrosis (<3 kPa). Increased MRE-associated liver stiffness was associated with increased risk for HCC, decompensation and mortality in a dose-dependent fashion but not with MACE or extrahepatic cancer, implicating a significant role for MRE in liver-related events and mortality; however, further studies are warranted to explore its role in MACE and extrahepatic cancer.
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DOI：
10.1002/hep.26455
发表时间：
2013-12
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Noureddin M;Lam J;Peterson MR;Middleton M;Hamilton G;Le TA;Bettencourt R;Changchien C;Brenner DA;Sirlin C;Loomba R
通讯作者：
Loomba R
影响因子：
7.6
作者：
Nakajima, Atsushi;Eguchi, Yuichiro;Yoneda, Masato;Imajo, Kento;Tamaki, Nobuharu;Suganami, Hideki;Nojima, Toshiaki;Tanigawa, Ryohei;Iizuka, Masakazu;Iida, Yuki;Loomba, Rohit
通讯作者：
Loomba, Rohit
DOI：
10.1002/hep.31845
发表时间：
2021-11
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.5
作者：
Hong, Chai Yeong;Sinn, Dong Hyun;Gwak, Geum-Youn
通讯作者：
Gwak, Geum-Youn
影响因子：
3.6
作者：
Niikura, Toshihiro;Imajo, Kento;Nakajima, Atsushi
通讯作者：
Nakajima, Atsushi