Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study.
Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study.
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DOI：
10.1038/s41380-020-00911-3
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发表时间：
2021-07
影响因子：
11
通讯作者：
McLean SA
中科院分区：
文献类型：
--
作者：
Kessler RC;Ressler KJ;House SL;Beaudoin FL;An X;Stevens JS;Zeng D;Neylan TC;Linnstaedt SD;Germine LT;Musey PI Jr;Hendry PL;Sheikh S;Storrow AB;Jones CW;Punches BE;Datner EM;Mohiuddin K;Gentile NT;McGrath ME;van Rooij SJ;Hudak LA;Haran JP;Peak DA;Domeier RM;Pearson C;Sanchez LD;Rathlev NK;Peacock WF;Bruce SE;Miller MW;Joormann J;Barch DM;Pizzagalli DA;Sheridan JF;Smoller JW;Pace TWW;Harte SE;Elliott JM;Harnett NG;Lebois LAM;Hwang I;Sampson NA;Koenen KC;McLean SA
这是AURORA多中心纵向研究的结果的初步报告，该研究对创伤后生活经历后寻求急诊科（艾德）治疗的参与者进行了创伤后神经精神后遗症（APNS）的研究。我们专注于n=666参与者提出ED后，机动车碰撞（MVC）和研究协会的参与者的社会人口统计学和参与者报告的MVC特征与8周的创伤后应激障碍（PTSD）调整前MVC PTSD和介导的创伤周围症状和2周的急性应激障碍（ASD）。创伤周围症状、ASD和PTSD采用自我报告量表进行评估。8周PTSD患病率相对较高（42.0%），与参与者性别（女性），低社会经济地位（教育和收入）以及MVC严重程度的几个自我报告指标呈正相关。这些关联中的大多数完全由创伤周围症状介导，并且在较小程度上由ASD介导，这表明创伤后的前2周可能是干预以预防和降低PTSD风险的独特重要时间段。这一观察结果，再加上预测因子之间介导途径的相对强度的实质性变化，提出了多样化和潜在复杂的潜在生物和心理过程的可能性，这些过程仍有待于对丰富和不断发展的AURORA数据进行更深入的分析。
This is the initial report of results from the AURORA multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience. We focus on n=666 participants presenting to EDs following a motor vehicle collision (MVC) and examine associations of participant socio-demographic and participant-reported MVC characteristics with 8-week posttraumatic stress disorder (PTSD) adjusting for pre-MVC PTSD and mediated by peritraumatic symptoms and 2-week acute stress disorder (ASD). Peritraumatic Symptoms, ASD, and PTSD were assessed with self-report scales. Eight-week PTSD prevalence was relatively high (42.0%) and positively associated with participant sex (female), low socioeconomic status (education and income), and several self-report indicators of MVC severity. Most of these associations were entirely mediated by peritraumatic symptoms and, to a lesser degree, ASD, suggesting that the first 2 weeks after trauma may be a uniquely important time period for intervening to prevent and reduce risk of PTSD. This observation, coupled with substantial variation in the relative strength of mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated with more in-depth analyses of the rich and evolving AURORA data.
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影响因子：
11
作者：
McLean, Samuel A.;Ressler, Kerry;Kessler, Ronald
通讯作者：
Kessler, Ronald
影响因子：
11
作者：
Dean KR;Hammamieh R;Mellon SH;Abu-Amara D;Flory JD;Guffanti G;Wang K;Daigle BJ Jr;Gautam A;Lee I;Yang R;Almli LM;Bersani FS;Chakraborty N;Donohue D;Kerley K;Kim TK;Laska E;Young Lee M;Lindqvist D;Lori A;Lu L;Misganaw B;Muhie S;Newman J;Price ND;Qin S;Reus VI;Siegel C;Somvanshi PR;Thakur GS;Zhou Y;PTSD Systems Biology Consortium;Hood L;Ressler KJ;Wolkowitz OM;Yehuda R;Jett M;Doyle FJ 3rd;Marmar C
通讯作者：
Marmar C
影响因子：
6.9
作者：
Koenen KC;Ratanatharathorn A;Ng L;McLaughlin KA;Bromet EJ;Stein DJ;Karam EG;Meron Ruscio A;Benjet C;Scott K;Atwoli L;Petukhova M;Lim CCW;Aguilar-Gaxiola S;Al-Hamzawi A;Alonso J;Bunting B;Ciutan M;de Girolamo G;Degenhardt L;Gureje O;Haro JM;Huang Y;Kawakami N;Lee S;Navarro-Mateu F;Pennell BE;Piazza M;Sampson N;Ten Have M;Torres Y;Viana MC;Williams D;Xavier M;Kessler RC
通讯作者：
Kessler RC
影响因子：
6.9
作者：
Roberts, A. L.;Gilman, S. E.;Breslau, J.;Breslau, N.;Koenen, K. C.
通讯作者：
Koenen, K. C.
影响因子：
--
作者：
KESSLER, RC;SONNEGA, A;NELSON, CB
通讯作者：
NELSON, CB