Case series: fractional anisotropy along the trajectory of selected white matter tracts in adolescents born preterm with ventricular dilation.

Case series: fractional anisotropy along the trajectory of selected white matter tracts in adolescents born preterm with ventricular dilation.
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DOI:
10.1177/0883073812449693
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发表时间:
2013-06
影响因子:
1.9
通讯作者:
Feldman HM
Feldman HM
中科院分区:
医学4区
文献类型:
--
作者:
Myall NJ;Yeom KW;Yeatman JD;Gaman-Bean S;Feldman HM

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该病例系列评估了3例继发于脑室内出血的未分流脑室扩张的早产青少年的白色微结构。将受试者(年龄12-17岁,胎龄26-29周,出生体重825-1624 g)与3名足月对照组(13-17岁,39-40周,3147-3345 g)和3名未发生脑室扩张的早产青少年(10-13岁,26-29周,630-1673 g)进行比较。纤维束造影采用2个感兴趣区域的方法重建了以下白色物质束:上级纵束/弓状束、下纵束、下额枕束、钩束和皮质脊髓束。受试者表现出增加的分数各向异性和分数各向异性的模式的变化沿着轨迹的束邻近侧脑室。在分数各向异性增加的区域的张量形状表现出增加的线性各向异性的平面和球形各向异性的代价。这些结果表明,增加轴突堆积密度和变直的纤维继发于脑室扩大。
This case series assesses white matter microstructure in 3 adolescents born preterm with nonshunted ventricular dilation secondary to intraventricular hemorrhage. Subjects (ages 12–17 years, gestational age 26–29 weeks, birth weight 825–1624 g) were compared to 3 full-term controls (13–17 years, 39–40 weeks, 3147–3345 g) and 3 adolescents born preterm without ventricular dilatation (10–13 years, 26–29 weeks, 630–1673 g). Tractography using a 2 region of interest method reconstructed the following white matter tracts: superior longitudinal/arcuate fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, and corticospinal tract. Subjects showed increased fractional anisotropy and changes in the pattern of fractional anisotropy along the trajectory of tracts adjacent to the lateral ventricles. Tensor shape at areas of increased fractional anisotropy demonstrated increased linear anisotropy at the expense of planar and spherical anisotropy. These findings suggest increased axonal packing density and straightening of fibers secondary to ventricular enlargement.
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