The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate.
The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate.
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DOI：
10.1016/j.clp.2008.07.014
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发表时间：
2008-12
影响因子：
2.1
通讯作者：
Ment LR
中科院分区：
文献类型：
--
作者：
McCrea HJ;Ment LR
脑室内出血发生在20 - 25%的极低出生体重早产儿中，可能与严重的短期和长期后遗症有关。在新生儿期，IVH的婴儿有出血后脑积水和脑室周围白质软化的风险，而多达75%的脑实质出血患者在随访时出现明显的神经发育障碍。由于IVH的持续流行以及这种疾病的重大医学和社会影响，已经探索了许多产后药物预防策略。这些必须解决这种对发育中大脑的损伤的环境和遗传原因，随机临床预防试验应提供长期的神经发育随访，以评估早产，损伤和药物干预对发育中大脑的影响。
Intraventricular hemorrhage occurs in 20 – 25% of very low birth weight preterm neonates and may be associated with significant short- and long-term sequelae. In the newborn period, infants with IVH are at risk for both post-hemorrhagic hydrocephalus and periventricular leukomalacia, while as many as 75% of those with parenchymal involvement of hemorrhage suffer significant neurodevelopmental disability at follow-up. Because of the persistent prevalence of IVH and the significant medical and societal impact of this disease, numerous postnatal pharmacologic prevention strategies have been explored. These must address both the environmental and genetic causes of this injury to developing brain, and randomized clinical prevention trials should provide long-term neurodevelopmental follow-up to assess the impact of preterm birth, injury and pharmacologic intervention on developing brain.
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