Pre-radiographic osteoarthritic changes are highly prevalent in the medial patella and medial posterior femur in older persons: Framingham OA study.
Pre-radiographic osteoarthritic changes are highly prevalent in the medial patella and medial posterior femur in older persons: Framingham OA study.
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在老年人的内侧the骨和内侧股骨中，射线照相前骨关节炎的变化非常普遍：Framingham OA研究。
DOI：
10.1016/j.joca.2013.10.007
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发表时间：
2014-01
影响因子：
7
通讯作者：
Guermazi, A.
中科院分区：
文献类型：
--
作者：
Hayashi, D.;Felson, D. T.;Niu, J.;Hunter, D. J.;Roemer, E. W.;Aliabadi, P.;Guermazi, A.
确定膝关节的哪些亚区具有高患病率的放射学检查前骨关节炎变化，即，在放射学检查正常的膝关节中，只能通过MRI检测到的软骨损伤和骨赘。获得机构审查委员会批准和所有参与者的书面知情同意书。数据收集自马萨诸塞州弗拉特的一个社区队列，涉及50-79岁的人群。受试者接受了负重膝关节后前位和外侧X线摄影，采用固定屈曲方案和1.5T MRI。纳入了无影像学骨关节炎的膝关节（胫股关节Kellgren Lawrence 0级，髌股关节无任何骨赘或关节间隙狭窄）。将膝关节分为14个软骨亚区和16个骨赘亚区，使用全器官磁共振成像评分半定量评估软骨损伤（0-6级）和骨赘（0-7级）的患病率和严重程度。696名参与者的平均年龄为62.3±8.4岁，平均体重指数为27.9±5.1 kg/m2。女性占研究样本的55.2%（384/696）。髌骨内侧亚区和髌骨外侧亚区的软骨损伤发生率（≥2级）分别为47.7%（332/696）和29.9%（208/696），股骨内侧前亚区和股骨内侧中央亚区的软骨损伤发生率分别为24.0%（167/696）和26.5%（184/696）。股骨后内侧亚区的骨赘（≥2级）患病率最高，为60.8%（423/696），其次是髌骨外侧亚区的34.0%（237/696）和髌骨内侧亚区的24.6%（171/696）。在所有其他次区域，这些病变的患病率低于上述百分比。MRI检测到的软骨损伤和骨赘在50-79岁人群中X线检查正常膝关节的内侧髌股关节和内侧后胫股关节中非常普遍。
To determine which subregions of the knee joint have a high prevalence of pre-radiographic osteoarthritic changes, i.e. cartilage damage and osteophytes that can only be detected by MRI, in radiographically normal knees. Institutional review board approval and written informed consent from all participants was obtained. Data was collected from a community cohort in Framingham, MA, involving people aged 50–79. Participants underwent weight-bearing posteroanterior and lateral knee radiography with the fixed-flexion protocol, and 1.5T MRI. Knees without radiographic osteoarthritis (Kellgren Lawrence grade 0 for the tibiofemoral joint and absence of any osteophytes or joint space narrowing in the patellofemoral joint) were included. The knee joint was divided into 14 subregions for cartilage and 16 subregions for osteophytes, and prevalence and severity of cartilage damage (grade 0–6) and osteophytes (grade 0–7) were semiquantitatively assessed using the Whole Organ Magnetic Resonance Imaging Score. The mean age of 696 participants was 62.3±8.4 years, and the mean body mass index was 27.9±5.1 kg/m2. Women comprised 55.2% of the study sample (384/696). Prevalence of cartilage damage (grade ≥2) was 47.7% (332/696) in the medial patellar and 29.9% (208/696) in patellar lateral subregions, and 24.0% (167/696) in femoral medial anterior and 26.5% (184/696) in femoral medial central subregions. Prevalence of osteophytes (grade ≥2) was highest at 60.8% (423/696) in the medial femoral posterior subregion, followed by 34.0% (237/696) in patellar lateral and 24.6% (171/696) in patellar medial subregions. For all other subregions, prevalence of these lesions was lower than the aforementioned percentages. MRI-detected cartilage damage and osteophytes are highly prevalent in the medial patellofemoral and medial posterior tibiofemoral joints in radiographically normal knees in persons aged 50–79.
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影响因子：
27.4
作者：
Hernandez-Molina, G.;Neogi, T.;Felson, D. T.
通讯作者：
Felson, D. T.
影响因子：
5.5
作者：
Duncan, R. C.;Hay, E. M.;Croft, P. R.
通讯作者：
Croft, P. R.
影响因子：
--
作者：
LaValley, MP;McLaughlin, S;Felson, DT
通讯作者：
Felson, DT
影响因子：
7
作者：
Link, TM;Sell, CA;Majumdar, S
通讯作者：
Majumdar, S
影响因子：
--
作者：
Roemer, Frank W.;Guermazi, Ali;Niu, Jingbo;Zhang, Yuqing;Mohr, Andreas;Felson, David T.
通讯作者：
Felson, David T.