Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection.
Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection.
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抗原特异性记忆调节CD4+ FOXP3+ T细胞控制对流感病毒感染的记忆反应。
DOI：
10.4049/jimmunol.1203140
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发表时间：
2013-04-01
期刊：
影响因子：
--
通讯作者：
Woodland DL
中科院分区：
文献类型：
--
作者：
Brincks EL;Roberts AD;Cookenham T;Sell S;Kohlmeier JE;Blackman MA;Woodland DL
调节性CD 4 + FoxP 3 + T细胞（Treg）是炎症反应的关键调节因子，并控制对病毒感染的细胞免疫反应的程度。然而，很少有人知道Treg如何在对以前遇到的病原体的记忆反应期间促进免疫调节。在这里，我们利用流感NP 311 -325/IAb II类四聚体来追踪对原发性和继发性流感病毒感染的抗原特异性Treg应答。在继发感染期间，抗原特异性记忆Treg显示相对于原发感染在肺引流淋巴结和肺实质中加速积累。记忆性Treg以MHC II类依赖性的抗原特异性方式有效地控制记忆性CD 8+细胞的体外增殖。当记忆性Treg在继发性感染之前耗尽时，抗原特异性记忆性CD 8 + T细胞应答的幅度增加，肺部炎症和气道细胞因子/趋化因子表达也增加。用幼稚Treg替换记忆Treg未能恢复继发感染期间记忆CD 8 T细胞应答的调节。总之，这些数据表明存在先前未描述的抗原特异性记忆Treg群体，其形成对二次流感病毒攻击的细胞免疫应答，并提供了在确定疫苗接种效力时考虑的额外参数。
Regulatory CD4+FoxP3+ T cells (Treg) are key regulators of inflammatory responses and control the magnitude of cellular immune responses to viral infections. However, little is known about how Treg contribute to immune regulation during memory responses to previously-encountered pathogens. Here we utilized influenza NP311-325/IAb Class II tetramers to track the antigen-specific Treg response to primary and secondary influenza virus infections. During secondary infections, antigen-specific memory Treg showed accelerated accumulation in the lung-draining lymph node and lung parenchyma relative to a primary infection. Memory Treg effectively controlled the in vitro proliferation of memory CD8+ cells in an antigen-specific fashion that was MHC class II dependent. When memory Treg were depleted prior to secondary infection, the magnitude of the antigen-specific memory CD8+ T cell response was increased, as was pulmonary inflammation and airway cytokine/chemokine expression. Replacement of memory Treg with naïve Treg failed to restore the regulation of the memory CD8 T cell response during secondary infection. Together, these data demonstrate the existence of a previously undescribed population of antigen-specific memory Treg that shape the cellular immune response to secondary influenza virus challenges and offer an additional parameter to consider when determining the efficacy of vaccinations.
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DOI：
10.1084/jem.20102110
发表时间：
2011-08-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kohlmeier JE;Reiley WW;Perona-Wright G;Freeman ML;Yager EJ;Connor LM;Brincks EL;Cookenham T;Roberts AD;Burkum CE;Sell S;Winslow GM;Blackman MA;Mohrs M;Woodland DL
通讯作者：
Woodland DL
DOI：
10.4049/jimmunol.1000423
发表时间：
2010-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fulton RB;Meyerholz DK;Varga SM
通讯作者：
Varga SM
影响因子：
4.4
作者：
Suvas, S;Azkur, AK;Rouse, BT
通讯作者：
Rouse, BT
DOI：
10.1073/pnas.0408197102
发表时间：
2005-01-11
影响因子：
11.1
作者：
Chen, ML;Pittet, MJ;Khazaie, K
通讯作者：
Khazaie, K
DOI：
10.1084/jem.20030171
发表时间：
2003-09-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Suvas S;Kumaraguru U;Pack CD;Lee S;Rouse BT
通讯作者：
Rouse BT