CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses.
CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses.
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DOI：
10.1084/jem.20030171
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发表时间：
2003-09-15
期刊：
影响因子：
--
通讯作者：
Rouse BT
中科院分区：
文献类型：
--
作者：
Suvas S;Kumaraguru U;Pack CD;Lee S;Rouse BT
天然存在的CD4+CD25+调节性T细胞似乎对防止自身反应性T细胞的活化很重要。这篇文章表明，CD8+ T细胞介导的免疫应答的急性病毒感染的幅度也受到CD4+CD25+ T调节细胞（Treg）的控制。因此，如果在用HSV感染之前用特异性抗CD25抗体耗尽天然Treg，则所得的对免疫显性肽SSIEFARL的CD8+ T细胞应答显著增强。这通过几种体外测量CD8+ T细胞反应性和通过直接测定CD8+ T细胞功能（如体内增殖和细胞毒性）的测定来显示。在CD25耗尽的动物中增强的反应性在三到四倍之间，在免疫应答的急性和记忆阶段都有明显的效果。令人惊讶的是，HSV感染导致Treg功能增强，这些细胞能够抑制CD8+ T细胞对病毒和不相关抗原的应答。我们的研究结果进行了讨论，无论是在如何病毒感染可能会暂时降低免疫力的其他传染性病原体和它们的应用疫苗。因此，在接种疫苗时控制抑制效应可以产生更有效的免疫力。
Naturally occurring CD4+CD25+ regulatory T cells appear important to prevent activation of autoreactive T cells. This article demonstrates that the magnitude of a CD8+ T cell–mediated immune response to an acute viral infection is also subject to control by CD4+CD25+ T regulatory cells (Treg). Accordingly, if natural Treg were depleted with specific anti-CD25 antibody before infection with HSV, the resultant CD8+ T cell response to the immunodominant peptide SSIEFARL was significantly enhanced. This was shown by several in vitro measures of CD8+ T cell reactivity and by assays that directly determine CD8+ T cell function, such as proliferation and cytotoxicity in vivo. The enhanced responsiveness in CD25-depleted animals was between three- and fourfold with the effect evident both in the acute and memory phases of the immune response. Surprisingly, HSV infection resulted in enhanced Treg function with such cells able to suppress CD8+ T cell responses to both viral and unrelated antigens. Our results are discussed both in term of how viral infection might temporarily diminish immunity to other infectious agents and their application to vaccines. Thus, controlling suppressor effects at the time of vaccination could result in more effective immunity.
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影响因子：
4.4
作者：
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影响因子：
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作者：
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