Rethinking sources of representative controls for the conduct of case-control studies in minority populations.
Rethinking sources of representative controls for the conduct of case-control studies in minority populations.
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DOI：
10.1186/1471-2288-13-71
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发表时间：
2013-05-31
影响因子：
4
通讯作者：
Ambrosone CB
中科院分区：
文献类型：
--
作者：
Bandera EV;Chandran U;Zirpoli G;McCann SE;Ciupak G;Ambrosone CB
在病例对照研究中，特别是在涉及少数群体的研究中，招募对照仍然是一个挑战。我们将通过随机数字拨号（RDD）招募的对照者的特征与通过教堂、健康活动和其他外展来源招募的社区对照者的特征进行了比较，这些对照者是参与妇女健康圈研究（一项乳腺癌病例对照研究）的非洲血统（AA）女性。还使用无条件逻辑回归计算优势比和 95% 置信区间，以评估纳入社区对照对与乳腺癌相关的选定变量的影响，并且两个对照组之间的分布存在显着差异。与社区对照组 (n=347) 相比，RDD 对照组 (n=207) 受教育年限更长，收入更高，体重指数更低，更有可能拥有私人保险，并且单身的可能性较小。虽然两组中未生育妇女的比例相似，但社区对照组往往生育更多孩子，第一个孩子的年龄较小，并且母乳喂养孩子的可能性较小。两组的膳食摄入量相似。与人口普查数据相比，RDD 和社区对照的组合似乎比单独的 RDD 对照更能代表一般人群。此外，社区群体的纳入对大多数变量的风险估计程度几乎没有影响，同时增强了统计功效。发现基于社区的招募是招募 AA 对照的有效且可行的方法。
Recruitment of controls remains a challenge in case–control studies and particularly in studies involving minority populations. We compared characteristics of controls recruited through random digit dialing (RDD) to those of community controls enrolled through churches, health events and other outreach sources among women of African ancestry (AA) participating in the Women’s Circle of Health Study, a case–control study of breast cancer. Odds ratios and 95% confidence intervals were also computed using unconditional logistic regression to evaluate the impact of including the community controls for selected variables relevant to breast cancer and for which there were significant differences in distribution between the two control groups. Compared to community controls (n=347), RDD controls (n=207) had more years of education and higher income, lower body mass index, were more likely to have private insurance, and less likely to be single. While the percentage of nulliparous women in the two groups was similar, community controls tended to have more children, have their first child at a younger age, and were less likely to breastfeed their children. Dietary intake was similar in the two groups. Compared to census data, the combination of RDD and community controls seems to be more representative of the general population than RDD controls alone. Furthermore, the inclusion of the community group had little impact on the magnitude of risk estimates for most variables, while enhancing statistical power. Community-based recruitment was found to be an efficient and feasible method to recruit AA controls.
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