Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats
Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats
复制标题
隔离饲养会导致大鼠社交和情绪功能异常，并改变谷氨酸和神经发育相关基因表达
DOI：
10.1016/j.pnpbp.2009.06.016
复制
发表时间：
2009-10
影响因子：
5.6
通讯作者：
Jia, Hongxiao
中科院分区：
文献类型：
--
作者：
Li, Nanxin;He, Shuchang;Zhao, Xiaohong;Meng, Qingxuan;Sun, Lei;Wu, Si;Jia, Hongxiao
隔离饲养可诱导大鼠出现各种认知异常，如逆转性学习障碍和前脉冲抑制减少。然而，很少有文献报道其对社会和情感功能的影响。在目前的研究中，我们的目的是解决这些问题，并表明，隔离饲养引起的侵略性和受损的社会识别，产生中度焦虑的影响，在高架十字迷宫，并导致在一个新的开放领域的多动症。在海马区NR 2A、NR 2B、PSD-95和SAP-102 mRNA表达显著上调，而在前额皮质区NR 2B mRNA表达显著下调。这项研究推进了社会隔离作为研究各种神经精神疾病的病因机制的动物模型的使用。
Isolation rearing induces various cognitive abnormalities such as reversal learning deficits and reduced prepulse inhibition in rats. However, there are few reports in the literature on its effects on social and emotional functions. In the current study we aimed to address these issues and demonstrated that isolation rearing induced aggression and impaired social recognition, produced moderate anxiogenic effects in the elevated-plus maze, and resulted in hyperactivity in a novel open field. We also found NR2A, NR2B, PSD-95 and SAP-102 mRNA expression were significantly up-regulated in the hippocampus while NR2B was down-regulated in prefrontal cortex in response to isolation rearing. This study advances the use of social isolation as an animal model for studying etiological mechanisms of various neuropsychiatric disorders.
登录
查看更多内容
DOI：
10.1523/jneurosci.4457-06.2007
发表时间：
2007-03-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cuthbert PC;Stanford LE;Coba MP;Ainge JA;Fink AE;Opazo P;Delgado JY;Komiyama NH;O'Dell TJ;Grant SG
通讯作者：
Grant SG
影响因子：
1.6
作者：
M. Bickerdike;I. K. Wright;C. Marsden
通讯作者：
M. Bickerdike;I. K. Wright;C. Marsden
影响因子：
3.3
作者：
Levine, J. B.;Youngs, R. M.;Konradi, C.
通讯作者：
Konradi, C.
影响因子：
3.8
作者：
S. Miachon;T. Rochet;B. Mathian;B. Barbagli;B. Claustrat
通讯作者：
S. Miachon;T. Rochet;B. Mathian;B. Barbagli;B. Claustrat
影响因子：
3.6
作者：
R. C. B. Silva;M. Brandão
通讯作者：
R. C. B. Silva;M. Brandão