Biomarkers in liver disease: emerging methods and potential applications.
Biomarkers in liver disease: emerging methods and potential applications.
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DOI：
10.1155/2012/437508
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发表时间：
2012
影响因子：
1.8
通讯作者：
Jackson AP
中科院分区：
文献类型：
--
作者：
Aithal GP;Guha N;Fallowfield J;Castera L;Jackson AP
生物标志物研究代表了肝病学中一个不断发展的领域。全球肝病的负担日益增加，直到疾病的自然史晚期才出现症状，可能需要数十年才能显现，存在侵入性参考测试（肝活检）来评估疾病严重程度，以及缺乏可靠的工具来评估治疗干预措施的有效性，这些都是本研究的一些关键驱动因素。美国国立卫生研究院（National Institute of Health）将生物标志物定义为“一种客观测量和评估的特征，可作为正常生物过程、致病过程或对治疗干预的药理学反应的指标”。此外，生物标志物可以根据其评估自然史（0型：预后）、生物活性（1型：对治疗的反应）和治疗效果（2型：临床疗效的替代品）[2]的能力划分为等级系统。肝脏疾病中发生的病理性损伤，包括脂肪变性、坏死炎症、细胞凋亡和纤维化，增加了潜在生物标志物的数量。此外，技术平台的进步使病理生理损伤的假定介质的发现呈指数级增长。为了达到诊断、预后和治疗的效果，越来越多的人需要将损伤的替代标记物与损伤的临床后果相结合。这个及时的特别版包括原创文章和评论的主题
Biomarker research represents an evolving area within hepatology. The growing burden of global liver disease, the absence of symptoms until late in the natural history of a disease which may take decades to manifest, the presence of an invasive reference test (liver biopsy) to assess disease severity, and the lack of robust tools to assess the efficacy of therapeutic interventions are some of the key drivers for this research.The National Institute of Health defines a biomarker as “A characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention”[1]. Moreover, biomarkers can be classified into hierarchical systems based on their ability to assess natural history (type 0: prognosis), biological activity (type 1: response to therapy), and therapeutic efficacy (type 2: surrogate for clinical efficacy)[2]. The spectrum of pathological injury that occurs in liver disease including steatosis, necroinflammation, apoptosis, and fibrosis enhances the pool of potential biomarkers. Furthermore, advances in technology platforms have created an exponential rise in the discovery of putative mediators of pathophysiological injury. This has been countered by the growing need to align surrogate markers of injury with clinical consequences of injury in order to achieve diagnostic, prognostic, and therapeutic effectiveness. This timely special edition comprises original articles and reviews in the subject
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影响因子：
24.5
作者：
Castéra, L;Hézode, C;Dhumeaux, D
通讯作者：
Dhumeaux, D
影响因子：
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作者：
Lawson, Adam;Hagan, Simone;Irving, William L.
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Sanyal, Arun J.
影响因子：
29.4
作者：
Matteoni, CA;Younossi, ZM;McCullough, AJ
通讯作者：
McCullough, AJ
影响因子：
1.9
作者：
Ripoll, Cristina;Lastra, Paola;Banares, Rafael
通讯作者：
Banares, Rafael