Recommendation to reconsider examining cannabis subtypes together due to opposing effects on brain, cognition and behavior.

Recommendation to reconsider examining cannabis subtypes together due to opposing effects on brain, cognition and behavior.
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DOI:
10.1016/j.neubiorev.2017.05.025
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发表时间:
2017-09
影响因子:
8.2
通讯作者:
Feldstein Ewing SW
Feldstein Ewing SW
中科院分区:
医学1区
文献类型:
--
作者:
Rømer Thomsen K;Callesen MB;Feldstein Ewing SW

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大麻的使用是全球的一个重大公共卫生问题。然而,我们仍然缺乏关于大麻对神经、认知和行为功能的长期影响的最基本的知识。这在一定程度上源于历史上衡量大麻的方式。为此目的,对大麻的大多数经验性审查将所有类型的大麻合并在一起。然而,这种方法掩盖了大麻类药物作用方式的差异。在这篇评论中,我们讨论了四氢大麻酚(THC)和大麻二酚(CBD)的不同性质及其对认知功能的相反影响。此外,我们讨论了过去二十年来大麻效力的增加,以及这如何影响早期数据对当代公共卫生评估的概括性。我们强调,今后迫切需要进行研究,将THC从CBD中分离出来,同时测量大麻效力的重要性,以更有效地揭示其对认知功能和其他健康问题的影响。
Cannabis use represents a major public health issue throughout the globe. Yet, we still lack the most fundamental knowledge on long-term effects of cannabis on neural, cognitive, and behavioral function. Part of this stems from how cannabis has been measured historically. To this end, most empirical examinations of cannabis have consolidated all types of cannabis collectively. However, this approach obscures differences in how cannabinoids operate. In this commentary, we address the contrasting properties of tetrahydrocannabinol (THC) and cannabidiol (CBD) and their opposing effects on cognitive function. In addition, we address the increase in cannabis potency throughout the past two decades and how that impacts generalizability of early data to evaluations of contemporary public health. We underscore the urgent need for future research to disaggregate examination of THC from CBD, along with the importance of measuring cannabis potency to more effectively unravel its influence on cognitive function and other health issues.
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