The evolution of Ebola virus: Insights from the 2013-2016 epidemic.

The evolution of Ebola virus: Insights from the 2013-2016 epidemic.
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DOI:
10.1038/nature19790
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发表时间:
2016-10-13
期刊:
影响因子:
64.8
通讯作者:
Andersen KG
Andersen KG
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Holmes EC;Dudas G;Rambaut A;Andersen KG

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2013-2016年西非埃博拉病毒病的流行规模前所未有,改变了我们对这种致命但偶尔出现的病毒的看法。这次疫情也标志着大规模实时分子流行病学的开始。在此,我们展示了埃博拉病毒基因组序列的进化分析如何为病毒起源,进化和流行期间的传播提供关键见解。我们为基础科学家,流行病学家,医疗从业者和其他疫情应对者提供病原体基因组测序的实用性和局限性的增强理解。这对我们追踪和控制未来传染病爆发的努力至关重要。
The 2013–2016 epidemic of Ebola virus disease in West Africa was of unprecedented magnitude and changed our perspective on this lethal but sporadically emerging virus. This outbreak also marked the beginning of large-scale real-time molecular epidemiology. Herein, we show how evolutionary analyses of Ebola virus genome sequences provided key insights into virus origins, evolution, and spread during the epidemic. We provide basic scientists, epidemiologists, medical practitioners, and other outbreak responders with an enhanced understanding of the utility and limitations of pathogen genomic sequencing. This will be crucially important in our attempts to track and control future infectious disease outbreaks.
DOI: 10.1093/ve/vew016
发表时间: 2016-01
期刊: Virus evolution
影响因子: 5.3
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影响因子: 64.8
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