TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction.
TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction.
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TMEM132a，一种新的通过Wnless(WLS)相互作用的Wnt信号通路调节因子。
DOI：
10.3389/fcell.2020.599890
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发表时间：
2020
影响因子：
5.5
通讯作者：
Niswander LA
中科院分区：
文献类型：
--
作者：
Li B;Niswander LA
Wnt信号通路在胚胎发育和成体组织稳态中起着不可或缺的作用。然而，涉及Wnt配体在信号发送细胞内的运输和从信号发送细胞分泌的调节机制仍然相对不确定。在这里，我们发现了一种新的Wnt信号通路的调节因子，称为跨膜蛋白132 A（TMEM 132 A）。我们的证据显示TMEM 132 A与Wnt配体转运蛋白Wntless（WLS）的物理和功能相互作用。我们表明，TMEM 132 A稳定Wnt配体，增强WLS-Wnt配体相互作用，并激活Wnt信号通路。我们的研究结果揭示了WNT信号发送细胞分泌WNT的基本方面的细胞机制。
Wnt signaling pathway plays indispensable roles in embryonic development and adult tissue homeostasis. However, the regulatory mechanisms involved in Wnt ligand trafficking within and secretion from the signal sending cells is still relatively uncharacterized. Here, we discover a novel regulator of Wnt signaling pathway called transmembrane protein 132A (TMEM132A). Our evidence shows a physical and functional interaction of TMEM132A with the Wnt ligand transporting protein Wntless (WLS). We show that TMEM132A stabilizes Wnt ligand, enhances WLS–Wnt ligand interaction, and activates the Wnt signaling pathway. Our results shed new light on the cellular mechanism underlying the fundamental aspect of WNT secretion from Wnt signal sending cells.
斜纹夜蛾 Su(var) 3-9 组蛋白 H3K9 三甲基转移酶的鉴定和表征及其在 AcMNPV 感染中的作用
影响因子：
3.7
作者：
Li B;Li S;Yin J;Zhong J
通讯作者：
Zhong J