Predominant synaptic potentiation and activation in the right central amygdala are independent of bilateral parabrachial activation in the hemilateral trigeminal inflammatory pain model of rats.
Predominant synaptic potentiation and activation in the right central amygdala are independent of bilateral parabrachial activation in the hemilateral trigeminal inflammatory pain model of rats.
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DOI：
10.1177/1744806918807102
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发表时间：
2018-01
期刊：
影响因子：
3.3
通讯作者：
Kato F
中科院分区：
文献类型：
--
作者：
Miyazawa Y;Takahashi Y;Watabe AM;Kato F
起源于外周的伤害性信号通过特定的传入和上行通路传递到大脑。脊髓-（三叉神经-）臂旁-杏仁核通路是介导从伤害性感受特异性上行神经元到中央杏仁核的信号的主要通路之一，中央杏仁核是参与厌恶信号相关情绪反应的边缘系统结构，包括疼痛的情绪方面。最近的研究表明，左、右中央杏仁核在伤害性反应的调节中起着不同的作用。使用大鼠的潜伏性福尔马林炎性疼痛模型，我们分析了右侧和左侧注射福尔马林后，大鼠上唇外侧臂旁核和中央杏仁核神经元的纤维之间形成的突触增强的左右差异，以及外侧臂旁核，中央杏仁核和基底外侧/外侧杏仁核中c-Fos表达的差异。尽管单侧福尔马林注射导致外侧臂旁核中c-Fos表达神经元的双侧显着增加，且具有轻微的投射侧依赖性，但突触后兴奋性电流振幅和中央杏仁核中c-Fos表达神经元数量的增加主要发生在右侧，无论炎症侧如何。虽然有没有显着的相关性c-Fos表达神经元的数目之间的外侧臂旁核和中央杏仁核的福尔马林注射的动物，这些数字之间的基底外侧杏仁核和中央杏仁核显着相关。因此得出的结论是，各种疼痛模型中报道的外侧臂旁核-中央杏仁核突触增强并不是简单的赫布可塑性，其中来自外侧臂旁核的输入引起外侧臂旁核-中央杏仁核增强，而是一种涉及特定机制的整合和适应性反应。右中央杏仁核。
Nociceptive signals originating in the periphery are conveyed to the brain through specific afferent and ascending pathways. The spino-(trigemino-)parabrachio-amygdaloid pathway is one of the principal pathways mediating signals from nociception-specific ascending neurons to the central amygdala, a limbic structure involved in aversive signal-associated emotional responses, including the emotional aspects of pain. Recent studies suggest that the right and left central amygdala play distinct roles in the regulation of nociceptive responses. Using a latent formalin inflammatory pain model of the rat, we analyzed the right–left differences in synaptic potentiation at the synapses formed between the fibers from the lateral parabrachial nucleus and central amygdala neurons as well as those in the c-Fos expression in the lateral parabrachial nucleus, central amygdala, and the basolateral/lateral amygdala after formalin injection to either the right or left side of the rat upper lip. Although the single-sided formalin injection caused a significant bilateral increase in c-Fos-expressing neurons in the lateral parabrachial nucleus with slight projection-side dependence, the increase in the amplitude of postsynaptic excitatory currents and the number of c-Fos-expressing neurons in the central amygdala occurred predominantly on the right side regardless of the side of the inflammation. Although there was no significant correlation in the number of c-Fos-expressing neurons between the lateral parabrachial nucleus and central amygdala in the formalin-injected animals, these numbers were significantly correlated between the basolateral amygdala and central amygdala. It is thus concluded that the lateral parabrachial nucleus-central amygdala synaptic potentiation reported in various pain models is not a simple Hebbian plasticity in which raised inputs from the lateral parabrachial nucleus cause lateral parabrachial nucleus-central amygdala potentiation but rather an integrative and adaptive response involving specific mechanisms in the right central amygdala.
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