Hemispheric differences in the number of parvalbumin-positive neurons in subdivisions of the rat basolateral amygdala complex.
Hemispheric differences in the number of parvalbumin-positive neurons in subdivisions of the rat basolateral amygdala complex.
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DOI：
10.1016/j.brainres.2017.10.028
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发表时间：
2018-01-01
期刊：
影响因子：
2.9
通讯作者：
Wilson MA
中科院分区：
文献类型：
--
作者：
Butler RK;Oliver EM;Fadel JR;Wilson MA
杏仁核是双侧颞叶脑区，在情绪处理中起着重要作用。过去对杏仁核的研究表明，杏仁核的过程和反应与特定的疼痛和恐惧行为有关。尽管杏仁核的功能差异，很少有研究已经进行，以表征是否存在解剖差异之间的左，右杏仁核。小清蛋白（PV）是皮质脑结构（如基底外侧杏仁核复合体（BLC））中抑制性中间神经元群体的表型标志物。本研究使用无偏体视学检查了成年雄性Long-Evans大鼠左右BLC中PV阳性神经元的数量。冠状切片通过喙尾侧的BLC范围进行PV的化学染色和光学分馏法被用来获得一个无偏估计的PV阳性神经元的数量通过BLC的细分。分析了杏仁核外侧区和基底外侧区的结构，并将其分为背外侧区、腹外侧区和腹内侧区，以及后区、前区和腹侧区。结果表明，有明显更多的PV阳性神经元在左基底外侧杏仁核相比，右，具有显着差异，特别是在后分部。PV神经元数量的这种差异有助于解释BLC在暴露于疼痛和恐惧刺激后的行为处理中的不同半球作用。
The amygdala is a bilateral temporal lobe brain region which plays an important role in emotional processing. Past studies on the amygdala have shown hemispheric differences in amygdalar processes and responses associated with specific pain and fear behaviors. Despite the functional differences in the amygdala, few studies have been performed to characterize whether anatomical differences exist between the left and right amygdala. Parvalbumin (PV) is a phenotypic marker for an inhibitory interneuronal population in cortical brain structures such as the basolateral amygdala complex (BLC). This study examined the number of PV-positive neurons in the left and right BLC of adult, male Long-Evans rats using unbiased stereology. Coronal sections through the rostral-caudal extent of the BLC were immunohistochemically-stained for PV and the optical fractionator method was used to obtain an unbiased estimate of the number of PV-positive neurons in subdivisions through the BLC. The lateral and basolateral amygdala divisions of the BLC were analyzed, were subdivided into the dorsolateral, ventrolateral and ventromedial and the posterior, anterior and ventral subdivisions, respectively. The results indicate that there are significantly more PV-positive neurons in the left basolateral amygdala compared to the right, with a significant difference specifically in the posterior subdivision. This difference in PV neuronal number could help explain the distinct hemispheric roles of the BLC in the behavioral processing following exposure to painful and fearful stimuli.
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