Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
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DOI：
10.1038/ng.3823
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发表时间：
2017-05
期刊：
影响因子：
30.8
通讯作者：
Bondy ML
中科院分区：
文献类型：
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作者：
Melin BS;Barnholtz-Sloan JS;Wrensch MR;Johansen C;Il'yasova D;Kinnersley B;Ostrom QT;Labreche K;Chen Y;Armstrong G;Liu Y;Eckel-Passow JE;Decker PA;Labussière M;Idbaih A;Hoang-Xuan K;Di Stefano AL;Mokhtari K;Delattre JY;Broderick P;Galan P;Gousias K;Schramm J;Schoemaker MJ;Fleming SJ;Herms S;Heilmann S;Nöthen MM;Wichmann HE;Schreiber S;Swerdlow A;Lathrop M;Simon M;Sanson M;Andersson U;Rajaraman P;Chanock S;Linet M;Wang Z;Yeager M;GliomaScan Consortium;Wiencke JK;Hansen H;McCoy L;Rice T;Kosel ML;Sicotte H;Amos CI;Bernstein JL;Davis F;Lachance D;Lau C;Merrell RT;Shildkraut J;Ali-Osman F;Sadetzki S;Scheurer M;Shete S;Lai RK;Claus EB;Olson SH;Jenkins RB;Houlston RS;Bondy ML
全基因组关联研究（GWAS）已经改变了我们对胶质瘤易感性的理解，但个体研究在识别风险位点方面的能力有限。我们对现有的GWAS和两个新的GWAS进行了荟萃分析，共12，496例病例和18，190例对照。我们在1p31.3发现了5个胶质母细胞瘤（GBM）的新基因座。（rs 12752552; P = 2.04 × 10−9，比值比（OR）= 1.22），11q14.1（rs11233250; P = 9.95 × 10−10，OR = 1.24），16p13.3（rs2562152; P = 1.93 × 10−8，OR = 1.21），16q12.1（rs 10852606; P = 1.29 × 10−11，OR = 1.18）和22q13.1（rs 2235573; P = 1.76 × 10−10，OR = 1.15），以及1q32.1处的非GBM肿瘤的8个位点（rs4252707; P = 3.34 × 10−9，OR = 1.19），1q44（rs12076373; P = 2.63 × 10−10，OR = 1.23），2q33.3（rs7572263; P = 2.18 × 10−10，OR = 1.20），3p14.1（rs11706832; P = 7.66 × 10−9，OR = 1.15），10q24.33（rs11598018; P = 3.39 × 10−8，OR = 1.14），11q21（rs7107785; P = 3.87 × 10−10，OR = 1.16），14q12（rs10131032; P = 5.07 × 10−11，OR = 1.33）和16p13.3（rs3751667; P = 2.61 × 10−9，OR = 1.18）。这些数据证实GBM和非GBM肿瘤的遗传易感性是高度不同的，这可能反映了不同的病因。
Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10−9, odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10−10, OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10−8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10−11, OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10−10, OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10−9, OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10−10, OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10−10, OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10−9, OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10−8, OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10−10, OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10−11, OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10−9, OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.
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DOI：
10.1056/nejmoa1407279
发表时间：
2015-06-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Eckel-Passow JE;Lachance DH;Molinaro AM;Walsh KM;Decker PA;Sicotte H;Pekmezci M;Rice T;Kosel ML;Smirnov IV;Sarkar G;Caron AA;Kollmeyer TM;Praska CE;Chada AR;Halder C;Hansen HM;McCoy LS;Bracci PM;Marshall R;Zheng S;Reis GF;Pico AR;O'Neill BP;Buckner JC;Giannini C;Huse JT;Perry A;Tihan T;Berger MS;Chang SM;Prados MD;Wiemels J;Wiencke JK;Wrensch MR;Jenkins RB
通讯作者：
Jenkins RB
影响因子：
7
作者：
Boyle AP;Hong EL;Hariharan M;Cheng Y;Schaub MA;Kasowski M;Karczewski KJ;Park J;Hitz BC;Weng S;Cherry JM;Snyder M
通讯作者：
Snyder M
影响因子：
64.5
作者：
Hnisz D;Abraham BJ;Lee TI;Lau A;Saint-André V;Sigova AA;Hoke HA;Young RA
通讯作者：
Young RA
影响因子：
64.8
作者：
Chen, Liuh-Yow;Redon, Sophie;Lingner, Joachim
通讯作者：
Lingner, Joachim
影响因子：
11.4
作者：
Gur, G;Rubin, C;Yarden, Y
通讯作者：
Yarden, Y