Renal vascular responses to static handgrip: role of muscle mechanoreflex.

Renal vascular responses to static handgrip: role of muscle mechanoreflex.
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肾血管对静态握力的反应:肌肉机械感受反射的作用。

DOI:
10.1152/ajpheart.00214.2003
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发表时间:
2003
期刊:
American journal of physiology. Heart and circulatory physiology
影响因子:
--
通讯作者:
Sinoway,LawrenceI
Sinoway,LawrenceI
中科院分区:
--
文献类型:
--
作者:
Momen,Afsana;Leuenberger,UrsA;Ray,ChesterA;Cha,Susan;Handly,Brian;Sinoway,LawrenceI

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在运动过程中,交感神经系统被激活,导致血管收缩。负责这种血管收缩的自主机制根据所研究的特定组织而变化。由于技术上的限制,试图检查人体肾循环的反射控制是困难的。在这份报告中,多普勒技术被用来检查肾血流速度在四个肌肉收缩范式在清醒的人。流速除以平均动脉血压,得到肾血管阻力指数(RVR)。重复静态握法(最大随意收缩的40%)使RVR增加76%。在握后停循环期间,RVR仍高于基线(2.1 ± 0.2 vs. 2.8 ± 0.2任意单位;P< 0.017),但仅为握末RVR值的40%。自发性肱二头肌收缩在收缩开始后10 s内增加RVR。这种效应与血压升高无关。最后,不自主的二头肌收缩也提高了RVR。我们的结论是,肌肉收缩引起肾血管收缩在清醒的人。这种反应的特点是一致的机械敏感传入的主要作用。这种说法是基于小的握后循环停搏反应和在肱二头肌不自主收缩时观察到的血管收缩。
During exercise, the sympathetic nervous system is activated, which causes vasoconstriction. The autonomic mechanisms responsible for this vasoconstriction vary based on the particular tissue being studied. Attempts to examine reflex control of the human renal circulation have been difficult because of technical limitations. In this report, the Doppler technique was used to examine renal flow velocity during four muscle contraction paradigms in conscious humans. Flow velocity was divided by mean arterial blood pressure to yield an index of renal vascular resistance (RVR). Fatiguing static handgrip (40% of maximal voluntary contraction) increased RVR by 76%. During posthandgrip circulatory arrest, RVR remained above baseline (2.1 ± 0.2 vs. 2.8 ± 0.2 arbitrary units;P< 0.017) but was only 40% of the end-grip RVR value. Voluntary biceps contraction increased RVR within 10 s of initiation of contraction. This effect was not associated with an increase in blood pressure. Finally, involuntary biceps contraction also raised RVR. We conclude that muscle contraction evokes renal vasoconstriction in conscious humans. The characteristic of this response is consistent with a primary role for mechanically sensitive afferents. This statement is based on the small posthandgrip circulatory arrest response and the vasoconstriction that was observed with involuntary biceps contraction.
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