Advances in measuring the effect of individual predictors of cardiovascular risk: the role of reclassification measures.

Advances in measuring the effect of individual predictors of cardiovascular risk: the role of reclassification measures.
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衡量心血管风险的个体预测因素的影响的进步:重新分类措施的作用。

DOI:
10.7326/0003-4819-150-11-200906020-00007
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发表时间:
2009-06-02
影响因子:
39.2
通讯作者:
Ridker PM
Ridker PM
中科院分区:
医学1区
文献类型:
--
作者:
Cook NR;Ridker PM

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风险预测模型在临床实践中广泛用于风险分层和分配治疗策略。新生物标志物的贡献主要基于受试者工作特征曲线下面积,但该指标对绝对风险的重要变化不敏感。最近提出了基于风险分层的方法来比较预测模型。这些包括重新分类校准统计,净重新分类改善(NRI)和综合歧视改善(IDI)。这项工作展示了使用的重新分类措施,并说明了他们的性能为众所周知的心血管疾病的风险预测在一个队列的妇女。这些措施旨在评估新模型和标志物改变风险分层和改变治疗决策的潜力。
Models for risk prediction are widely used in clinical practice to risk stratify and assign treatment strategies. The contribution of new biomarkers has largely been based on the area under the receiver operating characteristic curve, but this measure can be insensitive to important changes in absolute risk. Methods based on risk stratification have recently been proposed to compare predictive models. These include the reclassification calibration statistic, the net reclassification improvement (NRI), and the integrated discrimination improvement (IDI). This work demonstrates the use of reclassification measures, and illustrates their performance for well-known cardiovascular risk predictors in a cohort of women. These measures are targeted at evaluating the potential of new models and markers to change risk strata and alter treatment decisions.
DOI: 10.1001/jama.300.2.197
发表时间: 2008-07-09
影响因子: 120.7
作者:
Fowkes, F. G. R.;Murray, G. D.;Butcher, I.;Heald, C. L.;Lee, R. J.;Chambless, L. E.;Folsom, A. R.;Hirsch, A. T.;Dramaix, M.;deBacker, G.;Wautrecht, J-C.;Kornitzer, M.;Newman, A. B.;Cushman, M.;Sutton-Tyrrell, K.;Lee, A. J.;Price, J. F.;d'Agostino, R. B.;Murabito, J. M.;Norman, P. E.;Jamrozik, K.;Curb, J. D.;Masaki, K. H.;Rodriquez, B. L.;Dekker, J. M.;Bouter, L. M.;Heine, R. J.;Nijpels, G.;Stehouwer, C. D. A.;Ferrucci, L.;McDermott, M. M.;Stoffers, H. E.;Hooi, J. D.;Knottnerus, J. A.;Ogren, M.;Hedblad, B.;Witteman, J. C.;Breteler, M. M. B.;Hunink, M. G. M.;Hofman, A.;Criqui, M. H.;Langer, R. D.;Fronek, A.;Hiatt, W. R.;Hamman, R.;Resnick, H. E.;Guralnik, J.;McDermott, M. M.
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影响因子: 39.2
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影响因子: 3.6
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