Chromatin structure and the inheritance of epigenetic information.

Chromatin structure and the inheritance of epigenetic information.
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DOI:
10.1038/nrg2752
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发表时间:
2010-04
期刊:
Nature reviews. Genetics
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Although it is widely accepted that the regulation of the chromatin landscape is pivotal to conveying epigenetic phenomena, it is still unclear how a defined chromatin domain is reproduced following replication and transmitted from one generation to another. Here we review multiple mechanisms that contribute to the inheritance of epigenetic information with emphasis on the recycling of old histones following replication, the requirement for a positive feedback loop, long-range gene interactions, and the complex network of trans-acting factors.
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