Prognostic significance of tumor-infiltrating T cells in ovarian cancer: a meta-analysis.
Prognostic significance of tumor-infiltrating T cells in ovarian cancer: a meta-analysis.
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DOI：
10.1016/j.ygyno.2011.09.039
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发表时间：
2012-02
影响因子：
4.7
通讯作者：
Coukos G
中科院分区：
文献类型：
--
作者：
Hwang WT;Adams SF;Tahirovic E;Hagemann IS;Coukos G
肿瘤上皮成分中T细胞的存在，作为抗肿瘤免疫的组织学证据，在不同患者队列的多项研究中与生存优势相关。我们对评估肿瘤浸润淋巴细胞（TIL）对卵巢癌患者生存率的预后价值的研究进行了荟萃分析，并调查了与这种影响的变化相关的因素，包括患者特征，手术结局，肿瘤组织学和研究方案。已发表的评价TIL和患者生存率之间关系的研究被确定。描述性统计量、结局数据和研究质量从符合纳入标准的研究中提取。使用随机效应模型汇总研究中的风险比和95%置信区间。使用漏斗图研究发表偏倚，使用亚组分析和I2统计评估异质性。分析了10项合适的研究，包括1，815例卵巢癌患者。我们的研究结果表明，缺乏上皮内TIL与患者的生存率显著相关（合并HR：2.24，95%CI; 1.71-2.91）。鉴别了基于肿瘤细胞减积状态、评分方法和地理区域的TIL状态的预后价值的变化。上皮内TIL是卵巢癌预后的一个强有力的预测因子，并定义了一个特定的患者类别，在制定适当的治疗策略时应考虑其独特的肿瘤生物学。
The presence of T cells within the epithelial component of tumors, as histologic evidence of anti-tumor immunity, has been associated with a survival advantage in multiple studies across diverse patient cohorts. We performed a meta-analysis of studies evaluating the prognostic value of tumor-infiltrating lymphocytes (TIL) on survival among women with ovarian cancer and to investigate factors associated with variations in this effect, including patient characteristics, surgical outcomes, tumor histology, and study protocols. Published studies that evaluated the association between TIL and patient survival were identified. Descriptive statistics, outcome data, and study quality were extracted from studies that met inclusion criteria. Hazard ratios and 95% confidence intervals were pooled across studies using the random-effects model. Publication bias was investigated using a funnel plot and heterogeneity was assessed with subgroup analysis and I2 statistics. Ten suitable studies comprising 1,815 patients with ovarian cancer were analyzed. Our results demonstrate that a lack of intraepithelial TILs is significantly associated with a worse survival among patients (pooled HR: 2.24, 95% CI; 1.71–2.91). Variations in the prognostic value of TIL status based on debulking status, scoring method, and geographic regions were identified. Intraepithelial TILs are a robust predictor of outcome in ovarian cancer and define a specific class of patients, whose distinct tumor biology should be taken into account in devising appropriate therapeutic strategies.
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DOI：
10.1073/pnas.0509182102
发表时间：
2005-12-20
影响因子：
11.1
作者：
Sato, E;Olson, SH;Odunsi, K
通讯作者：
Odunsi, K
影响因子：
7.4
作者：
Alagkiozidis, Ioannis;Facciabene, Andrea;Coukos, George
通讯作者：
Coukos, George
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
2
作者：
Higgins, JPT;Thompson, SG
通讯作者：
Thompson, SG
影响因子：
7.4
作者：
Alagkiozidis I;Facciabene A;Tsiatas M;Carpenito C;Benencia F;Adams S;Jonak Z;June CH;Powell DJ Jr;Coukos G
通讯作者：
Coukos G