Microbiome Anomalies in Allogeneic Hematopoietic Cell Transplantation.

Microbiome Anomalies in Allogeneic Hematopoietic Cell Transplantation.
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DOI:
10.1146/annurev-med-052918-122440
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发表时间:
2020-01-27
影响因子:
10.5
通讯作者:
Jenq RR
Jenq RR
中科院分区:
医学1区
文献类型:
--
作者:
Schwabkey ZI;Jenq RR

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微生物组是人体的一个组成部分,可以调节各种疾病过程并影响预后,治疗反应,并发症和结果。异基因造血细胞移植在癌症治疗中的重要性导致了对微生物组与这种治疗方式之间相互作用的广泛研究,并开始导致微生物组靶向干预的临床试验。在这里,我们回顾了其中的一些发现,并描述了正在研究的操纵微生物组以获得有利结果的策略。
The microbiome is an integrated part of the human body that can modulate a variety of disease processes and affect prognosis, treatment response, complications and outcomes. The importance of allogeneic hematopoietic cell transplantation in cancer treatment has resulted in extensive investigations on the interaction between the microbiome and this treatment modality and is beginning to lead to clinical trials of microbiome-targeted interventions. Here we review some of these discoveries, as well as describe strategies being investigated to manipulate the microbiome for favorable outcomes.
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