Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities.
Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities.
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DOI：
10.3390/nu10111738
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发表时间：
2018-11-12
期刊：
影响因子：
5.9
通讯作者：
Majumder K
中科院分区：
文献类型：
--
作者：
Chakrabarti S;Guha S;Majumder K
最近的科学证据表明，食物蛋白质不仅是营养素，而且还可以调节人体的生理功能。这些生理功能主要由天然蛋白质序列中加密的一些肽调节。这些生物活性肽可以发挥有益健康的特性，因此被认为是开发营养保健品或功能食品的先导化合物。在过去的几十年中，已经鉴定了广泛的食物来源的生物活性肽序列，具有多种健康有益活性。然而，这些生物活性肽的商业应用已经被推迟，因为缺乏适当的和可扩展的生产方法，适当的探索的作用机制，高胃肠道消化率，可变的吸收率，以及缺乏精心设计的临床试验，以提供潜在的健康声明的实质性证据。这篇综述文章讨论了目前的技术，目前的生物活性肽生产技术的挑战，口服使用和胃肠道生物利用度的这些食源性生物活性肽，和整体的监管环境。
Recent scientific evidence suggests that food proteins not only serve as nutrients, but can also modulate the body’s physiological functions. These physiological functions are primarily regulated by some peptides that are encrypted in the native protein sequences. These bioactive peptides can exert health beneficial properties and thus are considered as a lead compound for the development of nutraceuticals or functional foods. In the past few decades, a wide range of food-derived bioactive peptide sequences have been identified, with multiple health beneficial activities. However, the commercial application of these bioactive peptides has been delayed because of the absence of appropriate and scalable production methods, proper exploration of the mechanisms of action, high gastro-intestinal digestibility, variable absorption rate, and the lack of well-designed clinical trials to provide the substantial evidence for potential health claims. This review article discusses the current techniques, challenges of the current bioactive peptide production techniques, the oral use and gastrointestinal bioavailability of these food-derived bioactive peptides, and the overall regulatory environment.
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影响因子：
6.1
作者：
Bejjani, Satyanarayana;Wu, Jianping
通讯作者：
Wu, Jianping
影响因子：
1.7
作者：
Epstein, Jay;Seitz, Rainer;Reddy, Ravi
通讯作者：
Reddy, Ravi
影响因子：
--
作者：
Chakrabarti S;Jahandideh F;Wu J
通讯作者：
Wu J
影响因子：
4.5
作者：
Coppens, P;da Silva, MF;Pettman, S
通讯作者：
Pettman, S
DOI：
10.1007/bf01202693
发表时间：
1993-07-01
期刊：
ZEITSCHRIFT FUR LEBENSMITTEL-UNTERSUCHUNG UND-FORSCHUNG
影响因子：
--
作者：
BUMBERGER, E;BELITZ, HD
通讯作者：
BELITZ, HD