Femoral neck structural properties are altered in adults with type 1 diabetes.
Femoral neck structural properties are altered in adults with type 1 diabetes.
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DOI：
10.1016/j.jdiacomp.2022.108308
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发表时间：
2022-11
影响因子：
3
通讯作者：
Shah, Viral N.
中科院分区：
文献类型：
--
作者：
Tinsley, Jake P.;Carpenter, R. Dana;Pyle, Laura L.;Snell-Bergeon, Janet K.;Sherk, Vanessa D.;Shah, Viral N.
旨在确定 1 型糖尿病 (T1D) 成人与未患糖尿病的健康成人相比，髋部几何形状的差异。在这项横断面研究中，纳入了 43 名患有 T1D 的成年人（平均年龄 56 岁，84% 女性，92% 白人，平均糖尿病病程 39 年，A1c 为 7.8%）和 40 名未患糖尿病的成年人（平均年龄 60 岁，80% 女性，77% 白人），他们在之前的研究中进行了髋部双能 X 射线骨密度测定 (DXA) 扫描。使用年龄、性别和体重指数控制的线性模型，对 T1D 成人和对照组成人的面骨矿物质密度 (aBMD) 和左侧股骨近端狭窄颈、粗隆间和股骨干区域的髋部结构特性测量进行了分析。 T1D 成人和对照组之间基于 DXA 的髋部（0.769 ± 0.132 与 0.900 ± 0.139 g/cm2，p = 0.07）或股骨颈（0.722 ± 0.116 与 0.849 ± 0.114 g/cm2，p = 0.09）区域的 aBMD 没有显着差异。当控制年龄、性别和 BMI 时，成人中基于 DXA 的髋部 aBMD（0.880 ± 0.022 对比 0.943 ± 0.020 g/cm2，p = 0.02）和股骨颈（0.750 ± 0.021 对比 0.812 ± 0.020 g/cm2，p = 0.02）区域显着较低T1D 比对照。成人 T1D 的所有三个髋部区域的皮质厚度均显着低于对照组（窄颈：0.169 ± 0.005 与 0.186 ± 0.005 cm，p = 0.011；转子间：0.388 ± 0.013 与 0.425 ± 0.012 cm，p = 0.017；股骨干： 0.529 ± 0.017 与 0.586 ± 0.016 厘米，p = 0.006）。此外，成人 T1D 的窄颈横截面积较小（3.06 ± 0.09 vs. 3.32 ± 0.08 cm2，p = 0.015），股骨干内皮质直径较高（2.23 ± 0.07 vs. 2.02 ± 0.06 cm，p = 0.011），并且屈曲比较高（皮质不稳定的指标）在转子间（9.22 ± 0.34 vs. 8.23 ± 0.32，p = 0.016）和股骨干（3.32 ± 0.15 vs. 2.89 ± 0.14，p = 0.016）区域。与对照组相比，患有 T1D 的成人在股骨近端形态方面有几个显着差异。这些形态差异可能会对股骨近端的机械完整性产生不利影响，从而导致跌倒时骨折的风险增加。
To determine differences in hip geometry in adults with type 1 diabetes (T1D) compared with healthy adults without diabetes. In this cross-sectional study, 43 adults with T1D (mean age 56 years, 84 % female, 92 % White, mean duration of diabetes of 39 years, A1c of 7.8 %) and 40 adults without diabetes (mean age 60 years, 80 % female, 77 % white) who had hip dual-energy x-ray absorptiometry (DXA) scans from previous studies were included. Areal bone mineral density (aBMD) and measures of hip structural properties at the narrow neck, intertrochanteric and femoral shaft regions of the left proximal femur were analyzed between adults with T1D and controls using linear models controlled for age, sex, and body mass index. There were no significant differences in DXA-based aBMD at the hip (0.769 ± 0.132 vs. 0.900 ± 0.139 g/cm2, p = 0.07) or femoral neck (0.722 ± 0.116 vs. 0.849 ± 0.114 g/cm2, p = 0.09) regions between adults with T1D and controls. When controlling for age, sex, and BMI, DXA-based aBMD at the hip (0.880 ± 0.022 vs. 0.943 ± 0.020 g/cm2, p = 0.02) and femoral neck (0.750 ± 0.021 vs. 0.812 ± 0.020 g/cm2, p = 0.02) regions were significantly lower in adults with T1D than controls. Cortical thickness was significantly lower in all three hip regions in adults with T1D than in controls (narrow-neck: 0.169 ± 0.005 vs. 0.186 ± 0.005 cm, p = 0.011; intertrochanteric: 0.388 ± 0.013 vs. 0.425 ± 0.012 cm, p = 0.017; femoral shaft: 0.529 ± 0.017 vs. 0.586 ± 0.016 cm, p = 0.006). Moreover, adults with T1D had a smaller cross-sectional area at the narrow-neck (3.06 ± 0.09 vs. 3.32 ± 0.08 cm2, p = 0.015), a higher femoral shaft endocortical diameter (2.23 ± 0.07 vs. 2.02 ± 0.06 cm, p = 0.011), and higher buckling ratios (an indicator of cortical instability) at the intertrochanteric (9.22 ± 0.34 vs. 8.23 ± 0.32, p = 0.016) and femoral shaft (3.32 ± 0.15 vs. 2.89 ± 0.14, p = 0.016) regions. Adults with T1D have several significant differences in proximal femur morphology compared with controls. These morphological differences may adversely affect the mechanical integrity of the proximal femur, thereby contributing to an increased risk of fracture in the event of a fall.
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影响因子：
4.1
作者：
Dyer SM;Crotty M;Fairhall N;Magaziner J;Beaupre LA;Cameron ID;Sherrington C;Fragility Fracture Network (FFN) Rehabilitation Research Special Interest Group
通讯作者：
Fragility Fracture Network (FFN) Rehabilitation Research Special Interest Group
影响因子：
2.5
作者：
Maser, Raelene E.;Kolm, Paul;Lenhard, M. James
通讯作者：
Lenhard, M. James
影响因子：
3.2
作者：
Ishikawa K;Fukui T;Nagai T;Kuroda T;Hara N;Yamamoto T;Inagaki K;Hirano T
通讯作者：
Hirano T
影响因子：
5.8
作者：
Joseph, Taisha, V;Caksa, Signe;Mitchell, Deborah M.
通讯作者：
Mitchell, Deborah M.
影响因子：
9.8
作者：
Garg, Rajesh;Chen, Zhao;Beck, Thomas;Cauley, Jane A.;Wu, Guanglin;Nelson, Dorothy;Lewis, Beth;LaCroix, Andrea;LeBoff, Meryl S.
通讯作者：
LeBoff, Meryl S.