Abnormal functional connectivity in radiologically isolated syndrome: A resting-state fMRI study.
Abnormal functional connectivity in radiologically isolated syndrome: A resting-state fMRI study.
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DOI：
10.1177/13524585231195851
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发表时间：
2023-10
影响因子：
5.8
通讯作者：
Melero, Helena
中科院分区：
文献类型：
--
作者：
Benito-Leon, Julian;del Pino, Ana Belen;Aladro, Yolanda;Cuevas, Constanza;Domingo-Santos, Angela;Sanchez-Seco, Victoria Galan;Labiano-Fontcuberta, Andres;Gomez-Lopez, Ana;Salgado-Camara, Paula;Costa-Frossard, Lucienne;Monreal, Enrique;de la Maza, Susana Sainz;Matias-Guiu, Jordi A.;Matias-Guiu, Jorge;Delgado-Alvarez, Alfonso;Montero-Escribano, Paloma;Martinez-Gines, Maria Luisa;Higueras, Yolanda;Ayuso-Peralta, Lucia;Malpica, Norberto;Melero, Helena
关键词：
放射隔离综合征(RIS)患者可能有精神和认知缺陷，这表明参与了主要的静息状态功能网络。尽管如此，人们对RIS涉及的神经网络知之甚少。使用静息状态功能磁共振成像(FMRI)检查RIS和健康对照组之间的功能连接性差异。使用独立成分分析对25名RIS患者和28名健康对照的静息状态fMRI数据进行分析；此外，还使用基于种子的相关分析来获得关于静息状态网络功能连通性的具体差异的更多信息。参与者还接受了神经心理测试。RIS患者在年龄、性别和受教育年限方面与健康对照组没有差异。然而，在记忆(语言和视觉空间)和执行功能方面，RIS患者的认知表现明显低于健康对照组。此外，液态智力也受到了影响。25名RIS患者中有12名(48%)未能通过至少一次认知测试，6名(24.0%)有认知障碍。与健康对照组相比，RIS患者的默认模式网络与右额中上回之间以及中央执行网络与右侧丘脑之间的功能连接性更高(pFDR<；0.05；更正)。此外，基于种子的相关性分析显示，RIS患者在神经网络的重要枢纽--后扣带皮质与右侧楔前叶之间表现出更高的功能连接性。RIS患者在主要静息状态神经网络中存在脑连接异常，在神经认知测试中表现较差。这个实体不应该被认为是多发性硬化症的“偶然发现”，而是一种完全非运动性(神经认知)的变异体。
Radiologically isolated syndrome (RIS) patients might have psychiatric and cognitive deficits, which suggests an involvement of major resting-state functional networks. Notwithstanding, very little is known about the neural networks involved in RIS. To examine functional connectivity differences between RIS and healthy controls using resting-state functional magnetic resonance imaging (fMRI). Resting-state fMRI data in 25 RIS patients and 28 healthy controls were analyzed using an independent component analysis; in addition, seed-based correlation analysis was used to obtain more information about specific differences in the functional connectivity of resting-state networks. Participants also underwent neuropsychological testing. RIS patients did not differ from the healthy controls regarding age, sex, and years of education. However, in memory (verbal and visuospatial) and executive functions, RIS patients’ cognitive performance was significantly worse than the healthy controls. In addition, fluid intelligence was also affected. Twelve out of 25 (48%) RIS patients failed at least one cognitive test, and six (24.0%) had cognitive impairment. Compared to healthy controls, RIS patients showed higher functional connectivity between the default mode network and the right middle and superior frontal gyri and between the central executive network and the right thalamus (pFDR < 0.05; corrected). In addition, the seed-based correlation analysis revealed that RIS patients presented higher functional connectivity between the posterior cingulate cortex, an important hub in neural networks, and the right precuneus. RIS patients had abnormal brain connectivity in major resting-state neural networks and worse performance in neurocognitive tests. This entity should be considered not an “incidental finding” but an exclusively non-motor (neurocognitive) variant of multiple sclerosis.
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影响因子：
4.8
作者：
Groppa S;Gonzalez-Escamilla G;Eshaghi A;Meuth SG;Ciccarelli O
通讯作者：
Ciccarelli O
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.
影响因子：
3.4
作者：
Beck, AT;Steer, RA;Ranieri, WF
通讯作者：
Ranieri, WF
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y