Sex hormones and lipoproteins in adolescent male offspring of parents with premature coronary heart disease and a control group.
Sex hormones and lipoproteins in adolescent male offspring of parents with premature coronary heart disease and a control group.
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患有早发冠心病的父母和对照组的青春期男性后代的性激素和脂蛋白。
DOI：
10.1016/s0022-3476(98)70062-9
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Wride,K
中科院分区：
文献类型：
--
作者：
Morrison,JA;Sprecher,DL;Biro,FM;Hansen,CA;Lucky,AW;Wride,K
目的比较青春期成熟，性类固醇激素和脂蛋白及其相互关系的男性后代的父母过早冠心病（例）和control group.DesignThis是一个横截面比较的情况下，一个对照组的成员10至15岁的age.Subjects和methodsOffspring招募患者名单的地区医生。对照组的成员是从地区学校招募的。体质量（kg/m2），血脂，脂蛋白，载脂蛋白，雌二醇，游离睾酮measured.ResultsDifferences在年龄没有显着，但后代更高，更重，更成熟。子代具有较高的总胆固醇和低密度脂蛋白胆固醇。子代在青春期早期雌二醇水平较低，但在青春期后期较高。在血脂参数的回归模型中，有家族史和体重的患者，游离睾酮是总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白的重要解释因子，雌二醇是载脂蛋白B的重要预测因子。睾酮和雌二醇解释的脂质参数的方差的百分比是small.ConclusionSex激素浓度似乎是温和的，但显着的预测脂蛋白和载脂蛋白浓度的后代和对照组的横断面分析。在控制青春期成熟后，后代和对照组的激素和脂质浓度不同。（J Pediatr 1998;133：526-32）
ObjectiveTo compare pubertal maturation, sex steroid hormones, and lipoproteins and their interrelationships in male offspring of parents with premature coronary heart disease (cases) and a control group.DesignThis was a cross-sectional comparison of cases and members of a control group 10 to 15 years of age.Subjects and methodsOffspring were recruited from patient lists of area physicians. Members of the control group were recruited from area schools. Body mass (kg/m2), serum lipids, lipoproteins, apolipoproteins, estradiol, and free testosterone were measured.ResultsDifferences in age were not significant, but offspring were taller, heavier, and more mature. Offspring had higher total and low density lipoprotein cholesterol. Offspring had lower estradiol levels in early puberty but higher levels in late puberty. With family history and body mass in the regression models for lipid parameters, free testosterone was a significant explanatory factor for total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein, and estradiol was a significant predictor for apolipoprotein B. The percent of the variance in the lipid parameters explained by testosterone and estradiol was small.ConclusionSex hormone concentrations appear to be modest but significant predictors of lipoprotein and apolipoprotein concentrations in offspring and a control group in cross-sectional analysis. After controlling for pubertal maturation, hormone and lipid concentrations differed in offspring and the control group. (J Pediatr 1998;133:526-32)
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