Medication exposure in pregnancy risk evaluation program: the prevalence of asthma medication use during pregnancy.
Medication exposure in pregnancy risk evaluation program: the prevalence of asthma medication use during pregnancy.
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DOI：
10.1007/s10995-012-1173-x
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发表时间：
2013-11
影响因子：
2.3
通讯作者：
Davis R
中科院分区：
文献类型：
--
作者：
Hansen C;Joski P;Freiman H;Andrade S;Toh S;Dublin S;Cheetham C;Cooper W;Pawloski P;Li DK;Beaton S;Kaplan S;Scott P;Hammad T;Davis R
哮喘是育龄妇女最常见的慢性疾病之一，发生在高达8%的怀孕。在一个大的不同队列中评估妊娠期间哮喘药物使用的流行率。我们在妊娠期药物暴露风险评估计划（MEPREP）中确定了2001年至2007年期间在11个美国健康计划中分娩活产婴儿的15至45岁女性。使用健康计划的行政和索赔数据，以及出生证明数据，我们确定了妇女从怀孕前90天到分娩期间服用哮喘药物的分娩情况。根据哮喘诊断和药物分配计算患病率（%）。在MEPREP队列中，有586，276名婴儿来自575，632名合格分娩。母亲哮喘患病率为6.7%，从2001年的5.5%上升到2007年的7.8%。共有9.7%（n= 55，914）的女性在妊娠期间接受了哮喘药物治疗。仅维持用药、仅急救用药和联合维持和急救用药的总体患病率分别为0.6%、6.7%和2.4%。在研究期间，仅维持使用的流行率从0.4%增加到0.8%，而仅急救使用的流行率从7.4%下降到5.8%。在这一基于大量人群的妊娠队列中，哮喘诊断的患病率随着时间的推移而增加。随着时间的推移，仅维持药物的分发增加，而仅急救药物的分发减少。
Asthma is one of the most common chronic diseases in women of reproductive age, occurring in up to 8% of pregnancies. Assess the prevalence of asthma medication use during pregnancy in a large diverse cohort. We identified women aged 15 to 45 years who delivered a live born infant between 2001 and 2007 across 11 U.S. health plans within the Medication Exposure in Pregnancy Risk Evaluation Program (MEPREP). Using health plans’ administrative and claims data, and birth certificate data, we identified deliveries for which women filled asthma medications from 90 days before pregnancy through delivery. Prevalence (%) was calculated for asthma diagnosis and medication dispensing. There were 586,276 infants from 575,632 eligible deliveries in the MEPREP cohort. Asthma prevalence among mothers was 6.7%, increasing from 5.5% in 2001 to 7.8% in 2007. A total of 9.7% (n=55,914) of women were dispensed asthma medications during pregnancy. The overall prevalence of maintenance-only medication, rescue-only medication, and combined maintenance and rescue medication was 0.6%, 6.7%, and 2.4% respectively. The prevalence of maintenance-only use doubled during the study period from 0.4% to 0.8%, while rescue-only use decreased from 7.4% to 5.8%. In this large population-based pregnancy cohort, the prevalence of asthma diagnoses increased over time. The dispensing of maintenance-only medication increased over time, while rescue-only medication dispensing decreased over time.
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影响因子：
9.8
作者：
Mitchell AA;Gilboa SM;Werler MM;Kelley KE;Louik C;Hernández-Díaz S;National Birth Defects Prevention Study
通讯作者：
National Birth Defects Prevention Study
影响因子：
7.2
作者：
Berg, Cynthia J.;MacKay, Andrea R.;Callaghan, William M.
通讯作者：
Callaghan, William M.
影响因子：
3.3
作者：
Namazy, JA;Schatz, M
通讯作者：
Schatz, M
影响因子：
2.6
作者：
Raebel, MA;Ellis, JL;Andrade, SE
通讯作者：
Andrade, SE
影响因子：
14.2
作者：
Enriquez, Rachel;Griffin, Marie R.;Hartert, Tina V.
通讯作者：
Hartert, Tina V.