Pain Sensitivity, Negative Affect, and Alcohol Use Disorder Status: A Moderated Mediation Study of Emotion Dysregulation.
Pain Sensitivity, Negative Affect, and Alcohol Use Disorder Status: A Moderated Mediation Study of Emotion Dysregulation.
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疼痛敏感性、负面情绪和酒精使用障碍状态：情绪失调的适度中介研究。
DOI：
10.3390/jcm10061321
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发表时间：
2021-03-23
影响因子：
3.9
通讯作者：
Jakubczyk A
中科院分区：
文献类型：
--
作者：
Kopera M;Trucco EM;Suszek H;Kobyliński P;Wiśniewski P;Wojnar M;Jakubczyk A
以前的工作表明，酒精使用障碍（AUD）患者的疼痛和情绪过程之间的关联可能与健康对照组不同。本研究调查疼痛敏感性是否介导了负面情绪和情绪失调之间的关联，以及这种关联是否在AUD状态中存在差异。样本包括165名被诊断患有AUD的个体和110名健康对照。感兴趣的是疼痛敏感性，评估与疼痛敏感性问卷，负面影响，评估与贝克抑郁量表，情绪调节障碍，评估与情绪调节量表的困难。年龄、生物学性别和当前疼痛严重程度作为协变量纳入。结果支持一个适度的部分调解模型，解释了44%的情绪失调的方差。研究结果表明，负面情绪与各组之间更高的疼痛敏感性有关。此外，疼痛敏感性部分介导的负面影响和情绪失调之间的关联，但在相反的方向取决于AUD状态。在健康对照组中，更大的疼痛敏感性与更好的情绪调节有关，而更大的疼痛敏感性导致AUD患者更大的情绪失调。情绪、疼痛和AUD的潜在神经生物学机制的潜在相似之处表明，针对疼痛的干预措施可能会提高适应性情绪调节技能，从而减少负面情绪及其对AUD患者疼痛敏感性的影响。
Previous work suggests that the association between pain and emotional processes among individuals with alcohol use disorder (AUD) may differ from healthy controls. This study investigates whether pain sensitivity mediates the association between negative affect and emotional dysregulation and whether this association differs across AUD status using moderated mediation. The sample included 165 individuals diagnosed with AUD and 110 healthy controls. Of interest was pain sensitivity, as assessed with the Pain Sensitivity Questionnaire, negative affect, as assessed with the Beck Depression Inventory, and emotional dysregulation, as assessed with the Difficulties in Emotional regulation Scale. Age, biological sex, and current pain severity were included as covariates. The results support a moderated partial mediation model that explained 44% of the variance in emotional dysregulation. The findings indicate that negative affect is related to higher pain sensitivity across groups. Moreover, pain sensitivity partially mediated the association between negative affect and emotional dysregulation, but in opposite directions depending on AUD status. Among healthy controls, greater pain sensitivity was related to better emotional regulation, while greater pain sensitivity led to greater emotional dysregulation among individuals with AUD. The potential parallels in the underlying neurobiological mechanisms of emotionality, pain, and AUD suggest that interventions targeting pain may improve adaptive affect regulation skills, which in turn could reduce negative affect and its effect on pain sensitivity among individuals with AUD.
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