Effects of STING stimulation on macrophages: STING agonists polarize into "classically" or "alternatively" activated macrophages?
Effects of STING stimulation on macrophages: STING agonists polarize into "classically" or "alternatively" activated macrophages?
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DOI：
10.1080/21645515.2017.1395995
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发表时间：
2018-02-01
影响因子：
4.8
通讯作者：
Kobayashi H
中科院分区：
文献类型：
--
作者：
Ohkuri T;Kosaka A;Nagato T;Kobayashi H
干扰素基因刺激因子（STING）是一种通过感应环GMP-腺苷酸（cGAMP）等配体介导I型干扰素（IFN）产生来促进抗肿瘤免疫的重要分子。我们最近的研究确实证明，肿瘤内注射cGAMP通过以STING依赖性方式在肿瘤微环境中积累活化的巨噬细胞而显示出有效的抗肿瘤应答。因为当巨噬细胞耗尽时cGAMP的抗肿瘤作用被废除，所以肿瘤部位中活化的巨噬细胞的存在对于有效的抗肿瘤免疫应答将是重要的。巨噬细胞显示表型多样性和可塑性，并根据刺激因子分为几组，例如M1和M2巨噬细胞分别为IFN-γ和IL-4。然而，STING刺激对巨噬细胞活化状态的影响仍有待评估。本文综述了巨噬细胞的复杂极化状态和STING刺激所引发的信号级联反应，并讨论了STING信号对巨噬细胞活化状态的影响，为今后的研究方向提供参考。
Stimulator of interferon genes (STING) was defined as an important molecule for promoting antitumor immunity through mediating type I interferon (IFN) production by sensing its ligands such as cyclic GMP-AMP (cGAMP). Our recent study indeed demonstrated that intratumoral injection of cGAMP showed effective antitumor responses via accumulating activated macrophages in the tumor microenvironment in a STING-dependent manner. Because the antitumor effect of cGAMP was abrogated when macrophages were depleted, the existence of the activated macrophages in the tumor site would be important for effective antitumor immune responses. Macrophages show phenotypic diversity and plasticity and are categorized into several groups by stimulation factors, e.g. IFN-γ and IL-4 for M1 and M2 macrophages, respectively. However, the impact of STING stimulation on the macrophage activation status remains to be evaluated. Here we summarize the complex polarized status of macrophages and the signaling cascade triggered by STING stimulation and also discuss the impact of STING signaling on the macrophage activation status for future directions.
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DOI：
10.1073/pnas.1512832112
发表时间：
2015-12-15
影响因子：
11.1
作者：
Demaria, Olivier;De Gassart, Aude;Gilliet, Michel
通讯作者：
Gilliet, Michel
影响因子：
8.8
作者：
Corrales L;Glickman LH;McWhirter SM;Kanne DB;Sivick KE;Katibah GE;Woo SR;Lemmens E;Banda T;Leong JJ;Metchette K;Dubensky TW Jr;Gajewski TF
通讯作者：
Gajewski TF
影响因子：
29
作者：
Vats, Divya;Mukundan, Lata;Chawla, Ajay
通讯作者：
Chawla, Ajay
影响因子：
10.1
作者：
Ohkuri, Takayuki;Ghosh, Arundhati;Okada, Hideho
通讯作者：
Okada, Hideho
影响因子：
32.4
作者：
Murray, Peter J.;Allen, Judith E.;Biswas, Subhra K.;Fisher, Edward A.;Gilroy, Derek W.;Goerdt, Sergij;Gordon, Siamon;Hamilton, John A.;Ivashkiv, Lionel B.;Lawrence, Toby;Locati, Massimo;Mantovani, Alberto;Martinez, Fernando O.;Mege, Jean-Louis;Mosser, David M.;Natoli, Gioacchino;Saeij, Jeroen P.;Schultze, Joachim L.;Shirey, Kari Ann;Sica, Antonio;Suttles, Jill;Udalova, Irina;van Ginderachter, Jo A.;Vogel, Stefanie N.;Wynn, Thomas A.
通讯作者：
Wynn, Thomas A.