Circadian rhythm disruption linked to skeletal muscle dysfunction in the Mexican Cavefish
Circadian rhythm disruption linked to skeletal muscle dysfunction in the Mexican Cavefish
复制标题
昼夜节律紊乱与墨西哥穴居鱼骨骼肌功能障碍有关
DOI：
10.1016/j.cub.2023.02.036
复制
发表时间：
2023
期刊：
影响因子：
9.2
通讯作者：
Rohner, Nicolas
中科院分区：
文献类型：
--
作者：
Olsen, Luke;Krishnan, Jaya;Banks, Charles;Hassan, Huzaifa;Rohner, Nicolas
已经清楚的是，外周组织中的生物钟起着重要的作用。例如，骨骼肌生物钟的破坏会导致胰岛素抵抗、肌节紊乱和肌肉无力1。有趣的是，洞穴鱼，这表现出一个中断的中央时钟，表现出类似的肌肉phenotypes2，3，4，提出了一个问题，他们是否是由改变中央或外围时钟。在这里，我们证明了时钟功能的墨西哥洞穴鱼Astyanax mexicanus的骨骼肌中的损失，这与大量基因的节律性降低和破坏夜间蛋白catalysts。一些已鉴定的基因与人类的代谢功能障碍有关。
It has become clear that circadian clocks in peripheral tissues play important functions. Disruption of the circadian clock in skeletal muscle, for example, results in insulin resistance, sarcomere disorganization, and muscle weakness1. Interestingly, cavefish, which exhibit a disrupted central clock, exhibit similar muscle phenotypes2,3,4, raising the question of whether they are caused by alterations to central or peripheral clocks. Here, we demonstrate a loss in clock function in the skeletal muscle of the Mexican CavefishAstyanax mexicanusthat is associated with reduced rhythmicity of a large number of genes and disrupted nocturnal protein catabolism. Some of the identified genes are associated with metabolic dysfunction in humans.
影响因子：
4.5
作者：
Katya L. Mack;James B. Jaggard;J. Persons;Emma Y. Roback;C. Passow;Bethany A. Stanhope;Estephany Ferrufino;Dai Tsuchiya;Sarah E Smith;Brian D. Slaughter;J. Kowalko;Nicolas Rohner;A. Keene;S. McGaugh
通讯作者：
Katya L. Mack;James B. Jaggard;J. Persons;Emma Y. Roback;C. Passow;Bethany A. Stanhope;Estephany Ferrufino;Dai Tsuchiya;Sarah E Smith;Brian D. Slaughter;J. Kowalko;Nicolas Rohner;A. Keene;S. McGaugh