The perspectives of UK personnel towards current killing practices for laboratory rodents.
The perspectives of UK personnel towards current killing practices for laboratory rodents.
复制标题
英国人员对目前实验室啮齿动物捕杀做法的看法。
DOI：
10.1038/s41598-023-31808-0
复制
发表时间：
2023-03-23
影响因子：
4.6
通讯作者：
Martin, Jessica E.
中科院分区：
文献类型：
--
作者：
Clarkson, Jasmine M.;Leach, Matthew C.;McKeegan, Dorothy E. F.;Martin, Jessica E.
啮齿动物是用于科学研究的主要物种，必须在工作完成后人道地杀死。在英国，这是由《1986年动物科学程序法》附表1规定的，其中列出了被认为能够人道处死的允许方法，包括过量麻醉剂，暴露于二氧化碳（CO2）气体，颈部脱位和通过撞击颅骨造成脑震荡。虽然所有这些都是允许的，但操作员选择方法的动机和个人操作员的偏好仍然未知。获得了219名实验室动物工作人员对实验室啮齿动物附表1杀灭方法的机构可用性和使用情况的意见。只有10%的参与者报告说，所有四种方法都可以在他们的机构，57.5%的受访者更喜欢颈椎脱位。对于CO2，只有18.6%的参与者报告使用了推荐的流量，而45.5%的参与者不知道使用的流量。我们强调迫切需要制定质量控制的培训方案，以提高对选择和应用杀人方法的了解和信心。我们提倡对捕杀实践进行持续审查，以确保最佳实践反映在立法中，并在捕杀过程中实现对实验室啮齿动物福利的最佳保护。
Rodents are the predominant species used for scientific research and must be humanely killed upon completion of the work. In the UK this is regulated by Schedule 1 of the Animals Scientific Procedures Act 1986, which lists permitted methodologies considered capable of humane killing, including overdose of an anaesthetic, exposure to carbon dioxide (CO2) gas, dislocation of the neck and concussion of the brain by striking the cranium. Although all are permitted, operator motivations behind method selection and individual operator preference remain unknown. The views of 219 laboratory animal personnel on institutional availability and use of Schedule 1 killing methods for laboratory rodents were obtained. Only 10% of participants reported that all four methods were available at their institution with 57.5% of respondents preferring cervical dislocation. For CO2, only 18.6% of participants reported using the recommended flow rate, while 45.5% did not know the flow rate employed. We highlight the urgent requirement for the development of quality-controlled training programmes, to improve knowledge and confidence in the selection and application of killing methods. We advocate for continuous review of killing practices to ensure best practice is reflected in legislation and achieve optimal protection of the welfare of laboratory rodents during killing.
登录
查看更多内容
影响因子：
2.4
作者：
通讯作者：
--
影响因子：
2.3
作者：
Niel, Lee;Stewart, Sarah A.;Weary, Daniel A.
通讯作者：
Weary, Daniel A.
影响因子：
2.4
作者：
Brunt MW;Améndola L;Weary DM
通讯作者：
Weary DM
影响因子：
3.2
作者：
LaFollette, Megan R.;Riley, Megan C.;Gaskill, Brianna N.
通讯作者：
Gaskill, Brianna N.
影响因子：
3
作者：
Flammer, Shannon Axiak;Eskes, Chantra;Weary, Dan
通讯作者：
Weary, Dan