Individual differences in vulnerability for self-injurious behavior: studies using an animal model.
Individual differences in vulnerability for self-injurious behavior: studies using an animal model.
复制标题
自残行为脆弱性的个体差异：使用动物模型的研究。
DOI：
10.1016/j.bbr.2010.10.012
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发表时间：
2011-02-02
影响因子：
2.7
通讯作者：
Devine, Darragh P.
中科院分区：
文献类型：
--
作者：
Muehlmann, Amber M.;Wilkinson, Jennifer A.;Devine, Darragh P.
自残行为 (SIB) 是一种使人衰弱的特征，在多种神经发育障碍中普遍存在。在大多数此类疾病中，有些人表现出 SIB，而另一些人则不然。然而，造成脆弱性的神经生物学机制实际上尚未被探索。我们在行为病理学动物模型中研究了导致 SIB 脆弱性或抵抗力的先天特征。对 18 只近亲繁殖的 Long-Evans 大鼠进行了筛选，以确定其对新环境的轻微压力的行为反应。然后根据中值划分将大鼠分为高反应者（HR；那些具有最高运动计数的大鼠）或低反应者（LR；那些具有较低运动计数的大鼠）。然后所有大鼠每天注射间接单胺激动剂匹莫林（150 mg/kg/天），持续10天，并评估自伤情况。所有 9 只 HR 大鼠和 9 只 LR 大鼠中的 5 只表现出自伤。与 LR 大鼠相比，HR 大鼠自伤时间更长，损伤的身体部位更多，造成的组织损伤面积更大。此外，对新奇压力的行为反应与这些自伤指标显着相关。 HR 大鼠对其他精神刺激作用指标（刻板印象、梳理毛发、运动、饲养）没有表现出显着增强的反应。因此，发生匹莫林诱导的 SIB 的脆弱性与先天应激反应性的行为测量呈正相关，并且可以基于先天应激反应性的行为测量来预测。这些发现表明，发育障碍中常见的特征可能有助于患者自残。这些发现还扩展了 HR/LR 模型预测脆弱性的行为病理学（例如毒瘾）的多样性。
Self-injurious behavior (SIB) is a debilitating characteristic that is prevalent across a broad spectrum of neurodevelopmental disorders. In most of these disorders, some individuals exhibit SIB, whereas others do not. However, the neurobiological mechanisms that confer vulnerability are virtually unexplored. We examined innate characteristics that contribute to vulnerability or resistance for SIB in an animal model of the behavioral pathology. Eighteen outbred Long-Evans rats were screened for behavioral responsiveness to the mild stress of a novel environment. The rats were then categorized as high responders (HR; those rats that had the highest locomotor counts) or low responders (LR; those rats that had lower locomotor counts) by median split. All the rats were then given daily injections of the indirect monoamine agonist pemoline (150 mg/kg/day) for 10 days, and self-injury was evaluated. All 9 HR rats and 5 of the 9 LR rats exhibited self-injury. The HR rats spent more time self-injuring, injured more body sites, and caused larger areas of tissue damage than the LR rats did. Furthermore, the behavioral responsiveness to novelty stress was significantly correlated with each of these measures of self-injury. The HR rats did not exhibit substantially enhanced responses on other measures of psychostimulant action (stereotypy, grooming, locomotion, rearing). Accordingly, vulnerability to develop pemoline-induced SIB is positively correlated with, and can be predicted based upon, a behavioral measure of innate stress responsiveness. These findings suggest that characteristics that are common in developmental disorders may help predispose afflicted individuals to self-injure. The findings also extend the variety of behavioral pathologies (e.g. drug addiction) for which the HR/LR model predicts vulnerability.
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影响因子：
12.8
作者：
Dellinger-Ness, Lorrie Ann;Handler, Leonard
通讯作者：
Handler, Leonard
影响因子：
17.3
作者：
CLARKE, DJ;WATERS, J;CORBETT, JA
通讯作者：
CORBETT, JA
DOI：
10.1016/s0074-7750(04)29004-8
发表时间：
2004-01-01
期刊：
INTERNATIONAL REVIEW OF RESEARCH IN MENTAL RETARDATION, VOL. 29
影响因子：
--
作者：
Cromwell, HC;King, BH
通讯作者：
King, BH
影响因子：
2.9
作者：
Cromwell, HC;King, BH;Levine, MS
通讯作者：
Levine, MS
影响因子：
3.6
作者：
Cromwell, HC;Levine, MS;King, BH
通讯作者：
King, BH