Cytomegalovirus Infection and Inflammation in Developing Brain.
Cytomegalovirus Infection and Inflammation in Developing Brain.
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DOI：
10.3390/v13061078
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发表时间：
2021-06-04
期刊：
影响因子：
--
通讯作者：
Brizić I
中科院分区：
文献类型：
--
作者：
Krstanović F;Britt WJ;Jonjić S;Brizić I
人巨细胞病毒（HCMV）是一种高度流行的疱疹病毒，可导致免疫功能低下的个体和免疫不成熟的胎儿和新生儿严重的疾病。大多数受感染的新生儿能够解决感染而不会出现后遗症。然而，在严重的情况下，先天性HCMV感染可导致危及生命的病理和具有低再生能力的器官系统的永久性损伤。尽管问题的严重性，HCMV感染的中枢神经系统（CNS）仍然没有充分的特点，日期。巨细胞病毒（CMV）具有严格的种属特异性，限制了HCMV在实验动物中的使用。新生小鼠腹腔注射小鼠巨细胞病毒（MCMV）后的感染有效地再现了CNS先天性HCMV感染的许多方面。一旦进入CNS，CMV靶向所有驻留的脑细胞，从而导致广泛的组织病理学和炎症的发展。来自驻留细胞和浸润免疫细胞的效应子功能有效地解决CNS中的急性MCMV感染。然而，宿主介导的炎症因子也可以介导脑CMV感染期间免疫病理学的发展。在这里，我们提供了一个概述巨细胞病毒感染的大脑，局部免疫反应的感染，并导致中枢神经系统后遗症的机制。
Human cytomegalovirus (HCMV) is a highly prevalent herpesvirus that can cause severe disease in immunocompromised individuals and immunologically immature fetuses and newborns. Most infected newborns are able to resolve the infection without developing sequelae. However, in severe cases, congenital HCMV infection can result in life-threatening pathologies and permanent damage of organ systems that possess a low regenerative capacity. Despite the severity of the problem, HCMV infection of the central nervous system (CNS) remains inadequately characterized to date. Cytomegaloviruses (CMVs) show strict species specificity, limiting the use of HCMV in experimental animals. Infection following intraperitoneal administration of mouse cytomegalovirus (MCMV) into newborn mice efficiently recapitulates many aspects of congenital HCMV infection in CNS. Upon entering the CNS, CMV targets all resident brain cells, consequently leading to the development of widespread histopathology and inflammation. Effector functions from both resident cells and infiltrating immune cells efficiently resolve acute MCMV infection in the CNS. However, host-mediated inflammatory factors can also mediate the development of immunopathologies during CMV infection of the brain. Here, we provide an overview of the cytomegalovirus infection in the brain, local immune response to infection, and mechanisms leading to CNS sequelae.
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鼠CMV引起的听力损失与内耳炎症和螺旋神经神经元的丧失有关。
影响因子：
6.7
作者：
Bradford RD;Yoo YG;Golemac M;Pugel EP;Jonjic S;Britt WJ
通讯作者：
Britt WJ
影响因子：
6
作者：
Arai, Y;Ishiwata, M;Tsutsui, Y
通讯作者：
Tsutsui, Y
DOI：
10.4049/jimmunol.181.3.2111
发表时间：
2008-08-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bantug GR;Cekinovic D;Bradford R;Koontz T;Jonjic S;Britt WJ
通讯作者：
Britt WJ
影响因子：
5.3
作者：
Carter, AR;Chen, CF;Segal, RA
通讯作者：
Segal, RA
影响因子：
--
作者：
Brizić I;Lisnić B;Brune W;Hengel H;Jonjić S
通讯作者：
Jonjić S