Auditory cortex tracks both auditory and visual stimulus dynamics using low-frequency neuronal phase modulation.
Auditory cortex tracks both auditory and visual stimulus dynamics using low-frequency neuronal phase modulation.
复制标题
听觉皮层使用低频神经元相位调制来跟踪听觉和视觉刺激动态
DOI：
10.1371/journal.pbio.1000445
复制
发表时间：
2010-08-10
期刊：
影响因子：
9.8
通讯作者：
Poeppel D
中科院分区：
文献类型：
--
作者：
Luo H;Liu Z;Poeppel D
自然主义的多感官信息如何在人类大脑中组合在一起？
跨感觉域构建多感觉信号的统一表示，在生态环境中是感知的基本特征。参与者观看视听电影的磁脑摄影（MEG）录音，低频神经元信息是基于在听觉和视觉流的信息的协同协调的基础上强大的（在单个试验中）和可用的信息（用于解析临时结构），这些刺激动力学在两个感觉方式中同时显示。在连续跟踪自然主义的视听流，携带动态多感官信息以及实时反映跨感官相互作用时，扮演着重要的“主动”角色。
当面对自然场景中的生态相关刺激时，我们的大脑需要从多个感官系统中协调信息，以创建外界的准确内部表示。在自然条件下，在线感知的神经生理学和人类成像研究越来越多地探索自然场景引起的响应特性。 - 在观看电影的单个试验中，皮质反应的阶段与刺激动力学的关键方面紧密相结合。遵循刺激的视觉特性，但也显示出对场景的听觉方面的敏感性。因此，在行为相关的刺激中，我们的工作有助于理解如何在人脑中分析和代表多感觉信息。
How is naturalistic multisensory information combined in the human brain? Based on MEG data we show that phase modulation of visual and auditory signals captures the dynamics of complex scenes. Integrating information across sensory domains to construct a unified representation of multi-sensory signals is a fundamental characteristic of perception in ecological contexts. One provocative hypothesis deriving from neurophysiology suggests that there exists early and direct cross-modal phase modulation. We provide evidence, based on magnetoencephalography (MEG) recordings from participants viewing audiovisual movies, that low-frequency neuronal information lies at the basis of the synergistic coordination of information across auditory and visual streams. In particular, the phase of the 2–7 Hz delta and theta band responses carries robust (in single trials) and usable information (for parsing the temporal structure) about stimulus dynamics in both sensory modalities concurrently. These experiments are the first to show in humans that a particular cortical mechanism, delta-theta phase modulation across early sensory areas, plays an important “active” role in continuously tracking naturalistic audio-visual streams, carrying dynamic multi-sensory information, and reflecting cross-sensory interaction in real time. When faced with ecologically relevant stimuli in natural scenes, our brains need to coordinate information from multiple sensory systems in order to create accurate internal representations of the outside world. Unfortunately, we currently have little information about the neuronal mechanisms for this cross-modal processing during online sensory perception under natural conditions. Neurophysiological and human imaging studies are increasingly exploring the response properties elicited by natural scenes. In this study, we recorded magnetoencephalography (MEG) data from participants viewing audiovisual movie clips. We developed a phase coherence analysis technique that captures—in single trials of watching a movie—how the phase of cortical responses is tightly coupled to key aspects of stimulus dynamics. Remarkably, auditory cortex not only tracks auditory stimulus dynamics but also reflects dynamic aspects of the visual signal. Similarly, visual cortex mainly follows the visual properties of a stimulus, but also shows sensitivity to the auditory aspects of a scene. The critical finding is that cross-modal phase modulation appears to lie at the basis of this integrative processing. Continuous cross-modal phase modulation may permit the internal construction of behaviorally relevant stimuli. Our work therefore contributes to the understanding of how multi-sensory information is analyzed and represented in the human brain.
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影响因子：
56.9
作者：
Calvert, GA;Bullmore, ET;David, AS
通讯作者：
David, AS
影响因子：
2.5
作者：
Foxe, JJ;Wylie, GR;Murray, MM
通讯作者：
Murray, MM
影响因子：
4.3
作者：
Chandrasekaran C;Trubanova A;Stillittano S;Caplier A;Ghazanfar AA
通讯作者：
Ghazanfar AA
DOI：
10.1093/cercor/bhl128
发表时间：
2007-09
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Bizley JK;Nodal FR;Bajo VM;Nelken I;King AJ
通讯作者：
King AJ
影响因子：
3.7
作者：
Calvert, GA
通讯作者：
Calvert, GA