Physiological and anatomical evidence for multisensory interactions in auditory cortex.
Physiological and anatomical evidence for multisensory interactions in auditory cortex.
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DOI：
10.1093/cercor/bhl128
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发表时间：
2007-09
期刊：
影响因子：
--
通讯作者：
King AJ
中科院分区：
文献类型：
--
作者：
Bizley JK;Nodal FR;Bajo VM;Nelken I;King AJ
最近的研究，几乎完全在灵长类动物中进行，已经表明，通常与特定模态的感觉处理相关的几个皮层区域受到其他感官的影响。在这里，我们证明使用单单位记录和估计的互信息，视觉刺激可以影响麻醉雪貂的听觉皮层的单位的活动。在许多情况下，这些单位也声学响应，并经常传输更多的信息，在他们的尖峰放电模式，以响应配对的视觉-听觉刺激比当任何一种方式是由本身。对于每个刺激，这一信息是由尖峰计数和尖峰定时的组合来传达的。即使在初级听觉区（初级听觉皮层[A1]和前听觉区[AAF]），也发现约15%的记录单位具有非听觉输入。这一比例增加，在更高的水平领域，位于腹侧A1/AAF和最高的前腹侧领域，其中近50%的单位被发现是视觉刺激只和进一步的四分之一，以视觉和听觉刺激。在每个领域内，对视觉刺激敏感的神经元的纯音反应特性与视觉无反应神经元的纯音反应特性没有任何系统性差异。神经示踪剂注射揭示了从视觉皮层到听觉皮层的直接输入，表明视觉反应的潜在来源。初级视觉皮层稀疏地投射到A1，而高级视觉区以特定的方式支配听觉区。这些数据表明，多感觉会聚和整合的功能共同所有的听觉皮层区域，但特别是在较高的地区普遍存在。
Recent studies, conducted almost exclusively in primates, have shown that several cortical areas usually associated with modality-specific sensory processing are subject to influences from other senses. Here we demonstrate using single-unit recordings and estimates of mutual information that visual stimuli can influence the activity of units in the auditory cortex of anesthetized ferrets. In many cases, these units were also acoustically responsive and frequently transmitted more information in their spike discharge patterns in response to paired visual-auditory stimulation than when either modality was presented by itself. For each stimulus, this information was conveyed by a combination of spike count and spike timing. Even in primary auditory areas (primary auditory cortex [A1] and anterior auditory field [AAF]), ~15% of recorded units were found to have nonauditory input. This proportion increased in the higher level fields that lie ventral to A1/AAF and was highest in the anterior ventral field, where nearly 50% of the units were found to be responsive to visual stimuli only and a further quarter to both visual and auditory stimuli. Within each field, the pure-tone response properties of neurons sensitive to visual stimuli did not differ in any systematic way from those of visually unresponsive neurons. Neural tracer injections revealed direct inputs from visual cortex into auditory cortex, indicating a potential source of origin for the visual responses. Primary visual cortex projects sparsely to A1, whereas higher visual areas innervate auditory areas in a field-specific manner. These data indicate that multisensory convergence and integration are features common to all auditory cortical areas but are especially prevalent in higher areas.
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影响因子：
2.5
作者：
Foxe, JJ;Wylie, GR;Murray, MM
通讯作者：
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作者：
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