Regulation of de novo methylation.
Regulation of de novo methylation.
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从头甲基化的调节。
DOI：
10.1007/978-3-0348-9118-9_6
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
C. Houlston
中科院分区：
文献类型：
--
作者：
R. Adams;H. Lindsay;A. Reale;C. Seivwright;S. Kass;M. Cummings;C. Houlston
脊椎动物的DNA，甚至大多数动物的DNA，都含有仅限于二核苷酸MG(其中M是5-甲基胞嘧啶)的甲基胞嘧啶，这已经成为一种教条。植物的DNA胞嘧啶甲基化比例较高，这主要是因为它们在三核苷酸序列MNG中有额外的甲基胞嘧啶(Belanger和Hepburn，1990)。并不是所有的CG(或CNG)序列都是甲基化的，但那些甲基化的序列是以组织特有的方式在细胞一代又一代地保持甲基化形式的。这种甲基化模式的维持被认为是催化甲基从S-腺苷蛋氨酸(ADOMet)转移到脱氧核糖核酸的酶的固有特性；这种酶被称为脱氧核糖核酸-(5-胞嘧啶)甲基转移酶或脱氧核糖核酸甲基酶。换句话说，甲基酶作用于新合成的DNA，在子链上的胞嘧啶上添加一个甲基，与亲本链上存在的MG二核苷酸(或MNG三核苷酸)序列中的鸟嘌呤配对。
It has become dogma that vertebrate DNA, and indeed the DNA of most animals, contains methylcytosine that is restricted to the dinucleotide MG (where M is 5-methylcytosine). Plants have a higher proportion of DNA cytosines methylated largely because they have additional methylcytosine in the trinucleotide sequence MNG (Belanger and Hepburn, 1990). Not all CG (nor CNG) sequences are methylated and yet those that are, are maintained in the methylated form from cell generation to generation in a tissue specific manner. This maintenance of methylation pattern is believed to be an intrinsic property of the enzyme catalysing the transfer of methyl groups from S-adenosyl methionine (AdoMet) to the DNA; an enzyme known as a DNA-(5-cytosine) methyltransferase or DNA methylase. In other words, the methylase acts on newly synthesized DNA to add a methyl group to cytosines on the daughter strand which are paired with guanines in MG dinucleotide (or MNG trinucleotide) sequences present on the parental strand.
通过 DNA 介导的基因转移改变基因型和表型。
DOI：
10.1126/science.7414320
发表时间：
1980
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Pellicer,A;Robins,D;Wold,B;Sweet,R;Jackson,J;Lowy,I;Roberts,JM;Sim,GK;Silverstein,S;Axel,R
通讯作者：
Axel,R
DOI：
10.1073/pnas.87.21.8252
发表时间：
1990-11-01
影响因子：
11.1
作者：
PFEIFER, GP;STEIGERWALD, SD;RIGGS, AD
通讯作者：
RIGGS, AD
DOI：
10.1073/pnas.81.22.6993
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
SANTI, DV;NORMENT, A;GARRETT, CE
通讯作者：
GARRETT, CE