Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.
复制标题
DOI：
10.1038/nature22364
复制
发表时间：
2017-04-26
期刊：
影响因子：
64.8
通讯作者：
Swanton C
中科院分区：
文献类型：
--
作者：
Abbosh C;Birkbak NJ;Wilson GA;Jamal-Hanjani M;Constantin T;Salari R;Le Quesne J;Moore DA;Veeriah S;Rosenthal R;Marafioti T;Kirkizlar E;Watkins TBK;McGranahan N;Ward S;Martinson L;Riley J;Fraioli F;Al Bakir M;Grönroos E;Zambrana F;Endozo R;Bi WL;Fennessy FM;Sponer N;Johnson D;Laycock J;Shafi S;Czyzewska-Khan J;Rowan A;Chambers T;Matthews N;Turajlic S;Hiley C;Lee SM;Forster MD;Ahmad T;Falzon M;Borg E;Lawrence D;Hayward M;Kolvekar S;Panagiotopoulos N;Janes SM;Thakrar R;Ahmed A;Blackhall F;Summers Y;Hafez D;Naik A;Ganguly A;Kareht S;Shah R;Joseph L;Marie Quinn A;Crosbie PA;Naidu B;Middleton G;Langman G;Trotter S;Nicolson M;Remmen H;Kerr K;Chetty M;Gomersall L;Fennell DA;Nakas A;Rathinam S;Anand G;Khan S;Russell P;Ezhil V;Ismail B;Irvin-Sellers M;Prakash V;Lester JF;Kornaszewska M;Attanoos R;Adams H;Davies H;Oukrif D;Akarca AU;Hartley JA;Lowe HL;Lock S;Iles N;Bell H;Ngai Y;Elgar G;Szallasi Z;Schwarz RF;Herrero J;Stewart A;Quezada SA;Peggs KS;Van Loo P;Dive C;Lin CJ;Rabinowitz M;Aerts HJWL;Hackshaw A;Shaw JA;Zimmermann BG;TRACERx consortium;PEACE consortium;Swanton C
非小细胞肺癌初次手术后复发的早期检测和新出现的亚克隆种植转移部位的特征可能提供新的治疗方法，以限制肿瘤复发。在早期肺癌的ctDNA中非侵入性地追踪肿瘤进化动力学的潜力尚未建立。在这里，我们在前100名TRACERx（TRACKING非小细胞肺癌通过治疗（Rx）演变）研究参与者中进行了ctDNA分析的肿瘤特异性系统发育方法，其中包括一名参与PEACE（晚期癌症环境死后评估）尸检研究的患者。我们确定了ctDNA释放的独立预测因子，并进行了肿瘤体积检测限分析。通过对术后血浆的盲法分析，我们观察了辅助化疗耐药的证据，并确定了注定要经历肺癌复发的患者。最后，我们表明系统发育ctDNA谱跟踪肺癌复发和转移的亚克隆性质，为ctDNA驱动的治疗研究提供了新的方法
The early detection of relapse following primary surgery for non-small cell lung cancer and the characterization of emerging subclones seeding metastatic sites might offer new therapeutic approaches to limit tumor recurrence. The potential to non-invasively track tumor evolutionary dynamics in ctDNA of early-stage lung cancer is not established. Here we conduct a tumour-specific phylogenetic approach to ctDNA profiling in the first 100 TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy (Rx)) study participants, including one patient co-recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and perform tumor volume limit of detection analyses. Through blinded profiling of post-operative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients destined to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastases, providing a new approach for ctDNA driven therapeutic studies
登录
查看更多内容
影响因子：
45.3
作者：
Pignon, Jean-Pierre;Tribodet, Helene;Le Chevalier, Thierry
通讯作者：
Le Chevalier, Thierry
DOI：
10.1093/bioinformatics/btt593
发表时间：
2014-03-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Zhang J;Kobert K;Flouri T;Stamatakis A
通讯作者：
Stamatakis A
影响因子：
3.8
作者：
Rhee J;Han SW;Oh DY;Kim JH;Im SA;Han W;Park IA;Noh DY;Bang YJ;Kim TY
通讯作者：
Kim TY
影响因子：
46.9
作者：
Newman AM;Lovejoy AF;Klass DM;Kurtz DM;Chabon JJ;Scherer F;Stehr H;Liu CL;Bratman SV;Say C;Zhou L;Carter JN;West RB;Sledge GW;Shrager JB;Loo BW Jr;Neal JW;Wakelee HA;Diehn M;Alizadeh AA
通讯作者：
Alizadeh AA
影响因子：
50.5
作者：
Jamal-Hanjani, M.;Wilson, G. A.;Swanton, C.
通讯作者：
Swanton, C.