The clinicopathologic characteristics and prognostic significance of triple-negativity in node-negative breast cancer.
The clinicopathologic characteristics and prognostic significance of triple-negativity in node-negative breast cancer.
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DOI：
10.1186/1471-2407-8-307
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发表时间：
2008-10-23
期刊：
影响因子：
3.8
通讯作者：
Kim TY
中科院分区：
文献类型：
--
作者：
Rhee J;Han SW;Oh DY;Kim JH;Im SA;Han W;Park IA;Noh DY;Bang YJ;Kim TY
三阴性乳腺癌被定义为雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体2 （HER-2）阴性，代表了具有不同生物学行为的乳腺癌的一个子集。我们探讨淋巴结阴性TN型乳腺癌的临床病理特点及预后指标。研究人员回顾了2000年1月至2003年6月在首尔国立大学医院接受治疗性手术的淋巴结阴性乳腺癌患者的医疗记录。评估临床病理变量和临床结果。在683例患者中，136例为TN型乳腺癌，529例为非TN型乳腺癌。TN乳腺癌与年龄越小（< 35岁，p = 0.003）、组织学和核分级越高（p < 0.001）相关。它还与与生物侵袭性相关的分子谱相关：bcl-2表达阴性（p < 0.001），表皮生长因子受体表达阳性（p = 0.003）， p53 （p < 0.001）和Ki67表达高水平（p < 0.00）。随访期间复发率（中位56.8个月），TN乳腺癌为14.7%，非TN乳腺癌为6.6% （p = 0.004）。TN乳腺癌患者的无复发生存期（RFS）明显短于非TN乳腺癌患者（4年RFS分别为85.5%和94.2%,p = 0.001）。在多变量分析中，年轻、近切缘和三阴性是较短RFS的独立预测因子。淋巴结阴性乳腺癌中，TN型乳腺癌复发率较高，临床病理特征较非TN型乳腺癌更具侵袭性。因此，TN乳腺癌应纳入淋巴结阴性乳腺癌的危险因素分析。
Triple-negative (TN) breast cancer, which is defined as being negative for the estrogen receptor (ER), the progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER-2), represents a subset of breast cancer with different biologic behaviour. We investigated the clinicopathologic characteristics and prognostic indicators of lymph node-negative TN breast cancer. Medical records were reviewed from patients with node-negative breast cancer who underwent curative surgery at Seoul National University Hospital between Jan. 2000 and Jun. 2003. Clinicopathologic variables and clinical outcomes were evaluated. Among 683 patients included, 136 had TN breast cancer and 529 had non-TN breast cancer. TN breast cancer correlated with younger age (< 35 y, p = 0.003), and higher histologic and nuclear grade (p < 0.001). It also correlated with a molecular profile associated with biological aggressiveness: negative for bcl-2 expression (p < 0.001), positive for the epidermal growth factor receptor (p = 0.003), and a high level of p53 (p < 0.001) and Ki67 expression (p < 0.00). The relapse rates during the follow-up period (median, 56.8 months) were 14.7% for TN breast cancer and 6.6% for non-TN breast cancer (p = 0.004). Relapse free survival (RFS) was significantly shorter among patients with TN breast cancer compared with those with non-TN breast cancer (4-year RFS rate 85.5% vs. 94.2%, respectively; p = 0.001). On multivariate analysis, young age, close resection margin, and triple-negativity were independent predictors of shorter RFS. TN breast cancer had higher relapse rate and more aggressive clinicopathologic characteristics than non-TN in node-negative breast cancer. Thus, TN breast cancer should be integrated into the risk factor analysis for node-negative breast cancer.
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影响因子：
3.8
作者：
Lee KH;Im SA;Oh DY;Lee SH;Chie EK;Han W;Kim DW;Kim TY;Park IA;Noh DY;Heo DS;Ha SW;Bang YJ
通讯作者：
Bang YJ
影响因子：
168.9
作者：
DELAROCHEFORDIERE, A;ASSELAIN, B;FOURQUET, A
通讯作者：
FOURQUET, A
影响因子：
8.4
作者：
NICHOLSON, RI;MCCLELLAND, RA;BLAMEY, RW
通讯作者：
BLAMEY, RW
DOI：
10.1073/pnas.0932692100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Sorlie, T;Tibshirani, R;Botstein, D
通讯作者：
Botstein, D
影响因子：
11.5
作者：
Carey, Lisa A.;Dees, E. Claire;Perou, Charles M.
通讯作者：
Perou, Charles M.