Intrarenal oxygenation by blood oxygenation level-dependent MRI in contrast nephropathy model: effect of the viscosity and dose.
Intrarenal oxygenation by blood oxygenation level-dependent MRI in contrast nephropathy model: effect of the viscosity and dose.
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DOI：
10.1002/jmri.23747
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发表时间：
2012-11
影响因子：
4.4
通讯作者：
Prasad, Pottumarthi V.
中科院分区：
文献类型：
--
作者：
Li, Lu-Ping;Franklin, Tammy;Du, Hongyan;Papadopoulou-Rosenzweig, Maria;Carbray, Joann;Solomon, Richard;Prasad, Pottumarthi V.
目的：在造影剂肾病(CIN)模型中，比较渗透压和造影剂粘度对造影剂血氧水平依赖(BOLD)磁共振成像(MRI)所确定的肾内氧合的影响。将24只SD大鼠随机分为5组。给予一氧化氮合酶抑制剂L NAME(10 mg/kg)、环氧合酶抑制剂吲哚美辛(10 mg/kg)或生理盐水，以及放射性对比剂碘二醇(高粘度，784或1600 mg I/kg)或异硫氰酸酯(高渗透压，1600 mg I/kg)。在西门子3T扫描仪上使用多梯度回波序列，在L名字(或生理盐水)、吲哚美辛(或生理盐水)和放射造影剂之后，采集BOLD MRI图像。以R2*(=1/T2*)作为肾髓质和皮质的BOLD MRI参数。采用混合效应模型和一阶自回归方差-协方差模型对数据进行分析。相同剂量碘的延髓R2*(mR2*)的变化幅度，在给药前组(303%比225.6%)和对照组(191.6%比-1.8%，p<；0.01)均大于异硫氰酸盐(P<；0.01)。与低剂量组相比，高剂量组的MR2*变化约为两倍(303%vs.133%，p<；0.01)。在BOLD MRI评估的肾脏氧合变化方面，放射造影剂的粘度似乎比渗透压起到更重要的作用。此外，碘化甘油可剂量依赖性地增加肾髓质缺氧程度。
To compare the effects of osmolality vs. viscosity of radio-contrast media on intra-renal oxygenation as determined by blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI) in a model of contrast induced nephropathy (CIN). 24 Sprague-Dawley rats were divided into five groups. Nitric oxide synthase inhibitor L-NAME (10mg/kg), cycloxygenase inhibitor indomethacin (10mg/kg), or saline, and radio-contrast iodixanol (high viscosity, 784 or 1600 mg I/kg) or iothalamate (high osmolality, 1600 mg I/kg) were administered. BOLD MRI images were acquired on Siemens 3T scanner using a multiple gradient recalled echo sequence at baseline, following L-NAME (or saline), indomethacin (or saline), and radio-contrast agents. R2* (=1/T2*) was used as the BOLD MRI parameter in renal medulla and cortex. Mixed-effects models with first order auto-regressive variance-covariance models were used to analyze the data. The magnitude of change in medullary R2* (MR2*) with same dose of iodine was larger with iodixanol compared to iothalalmate both in pre-treated groups (303% vs. 225.6%, <0.01) and the control group (191.6% vs. -1.8%, p <0.01). The MR2* change in high dose iodixanol was about twice compared to the low dose (303% vs. 133%, p<0.01). The viscosity of radio-contrast seems to play a more significant role than osmolality in terms of renal oxygenation changes as evaluated by BOLD MRI. Additionally, iodixanol induced a dose-dependent increase in renal medullary hypoxia.
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