Adaptive introgression across species boundaries in Heliconius butterflies.
Adaptive introgression across species boundaries in Heliconius butterflies.
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DOI：
10.1371/journal.pgen.1002752
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发表时间：
2012
期刊：
影响因子：
4.5
通讯作者：
Jiggins CD
中科院分区：
文献类型：
--
作者：
Pardo-Diaz C;Salazar C;Baxter SW;Merot C;Figueiredo-Ready W;Joron M;McMillan WO;Jiggins CD
广泛的文献表明，杂交发生在许多密切相关的物种之间，但是遗传渗入在适应性进化中的重要性仍不清楚，特别是在动物中。在这里，我们利用最近发现的一种调节红翅图案的基因，研究了渐进杂交在模拟蝴蝶之间转移适应性的作用。通过对与红色位点相连和未相连的区域进行测序，我们发现一个区域通过表型关联在四个物种（H. melpomene， H. cydno， H. timareta和H. heurippa）中显示出几乎完美的基因型。这个特殊的片段位于红色规范基因optix下游70 kb处，聚聚分析表明，H. melpomene的适应性等位基因反复渗入到H. cydno物种进化中。我们的分析方法补充了最近同一区域的基因组规模数据，并表明适应性基因渗入在产生适应性翅膀颜色多样性方面起着至关重要的作用。杂交发生在许多动物物种之间，然而其进化相关性仍然是一个有很大争议的问题。有些人认为杂交会导致基因组合不适应，从而进入进化的死胡同，而另一些人则认为种间杂交是一个极有可能推动进化的过程。我们通过探索红色翅膀颜色的起源来研究这个问题，这是一种自然选择下的特征，在密切相关的蝴蝶物种的适应性辐射中。通过对与红翼图案位点相关和非相关的基因区域进行测序，我们发现了支持多重杂交事件的实验证据，这些杂交事件介导了从H. melpomene到H. timareta的颜色适应性的获得。这种渗入使得H. timareta能够在<s:1>勒勒纪拟态景观中殖民新的适应高峰。通过这种方式，我们的结果支持了动物种间杂交构成促进多样化的遗传变异来源的观点。
It is widely documented that hybridisation occurs between many closely related species, but the importance of introgression in adaptive evolution remains unclear, especially in animals. Here, we have examined the role of introgressive hybridisation in transferring adaptations between mimetic Heliconius butterflies, taking advantage of the recent identification of a gene regulating red wing patterns in this genus. By sequencing regions both linked and unlinked to the red colour locus, we found a region that displays an almost perfect genotype by phenotype association across four species, H. melpomene, H. cydno, H. timareta, and H. heurippa. This particular segment is located 70 kb downstream of the red colour specification gene optix, and coalescent analysis indicates repeated introgression of adaptive alleles from H. melpomene into the H. cydno species clade. Our analytical methods complement recent genome scale data for the same region and suggest adaptive introgression has a crucial role in generating adaptive wing colour diversity in this group of butterflies. Hybridisation occurs between many animal species, however its evolutionary relevance is still a matter of great debate. While some argue that hybridisation leads to maladaptive gene combinations, and therefore to an evolutionary dead end, others consider interspecific hybridisation as a process with great potential to fuel evolution. We examine this question by exploring the origins of red wing colouration, a trait under natural selection, in the adaptive radiation of closely related species of Heliconius butterflies. By sequencing genetic regions both linked and unlinked to the red wing pattern locus, we found experimental evidence supporting multiple hybridisation events that have mediated the acquisition of colour adaptations from H. melpomene to H. timareta. This introgression has allowed H. timareta to colonise new fitness peaks in the Müllerian mimicry landscape. In this way, our results support the idea that interspecific hybridisation in animals constitutes a source of genetic variation that promotes diversification.
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影响因子：
--
作者：
Arnold ML;Martin NH
通讯作者：
Martin NH
DOI：
10.1126/science.1165448
发表时间：
2009-03-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anderson TM;vonHoldt BM;Candille SI;Musiani M;Greco C;Stahler DR;Smith DW;Padhukasahasram B;Randi E;Leonard JA;Bustamante CD;Ostrander EA;Tang H;Wayne RK;Barsh GS
通讯作者：
Barsh GS
影响因子：
4.5
作者：
Baxter SW;Nadeau NJ;Maroja LS;Wilkinson P;Counterman BA;Dawson A;Beltran M;Perez-Espona S;Chamberlain N;Ferguson L;Clark R;Davidson C;Glithero R;Mallet J;McMillan WO;Kronforst M;Joron M;Ffrench-Constant RH;Jiggins CD
通讯作者：
Jiggins CD
影响因子：
64.8
作者：
Jiggins, CD;Naisbit, RE;Mallet, J
通讯作者：
Mallet, J
影响因子：
3
作者：
Gaunt, Tom R.;Rodriguez, Santiago;Day, Ian N. M.
通讯作者：
Day, Ian N. M.