Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes.
Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes.
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Fas/CD95表面受体介导各种细胞类型的快速死亡，包括具有触发自身免疫潜力的自身反应性T细胞。在这里，我们提出了新的方面的Fas信号，定义了一个‘社会’层面的受体诱导的细胞凋亡。Fas刺激可迅速诱导相邻T细胞之间形成广泛的膜纳米管。这严重依赖于Rho GTP酶，而不是caspase的激活。通过这些纳米管可以观察到包括活性半胱氨酸天冬氨酸酶在内的膜和胞质元素的双向转移。具有Fas受体突变的自身免疫淋巴增殖性综合征患者的T淋巴细胞中，死亡信号的纳米管形成和细胞间交换存在缺陷。我们得出结论，纳米管介导的交换构成了一种新的细胞间通信形式，增强了相邻T细胞之间死亡信号的传播。
The Fas/CD95 surface receptor mediates rapid death of various cell types, including autoreactive T cells with the potential for triggering autoimmunity. Here, we present novel aspects of Fas signalling that define a ‘social’ dimension to receptor-induced apoptosis. Fas stimulation rapidly induces extensive membrane nanotube formation between neighbouring T cells. This is critically dependent on Rho GTPases but not on caspase activation. Bidirectional transfer of membrane and cytosolic elements including active caspases can be observed to occur via these nanotubes. Nanotube formation and intercellular exchanges of death signals are defective in T lymphocytes from patients with autoimmune lymphoproliferative syndrome harbouring mutations in the Fas receptor. We conclude that nanotube-mediated exchanges constitute a novel form of intercellular communication that augments the propagation of death signalling between neighbouring T cells.
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影响因子：
4.4
作者：
Horner, Heike;Frank, Carola;Stockmeyer, Bernhard
通讯作者：
Stockmeyer, Bernhard
影响因子：
4.8
作者：
Kischkel, FC;Lawrence, DA;Ashkenazi, A
通讯作者：
Ashkenazi, A
影响因子：
7.5
作者：
Gerdes, Hans-Hermann;Carvalho, Raquel Negrao
通讯作者：
Carvalho, Raquel Negrao
DOI：
10.1073/pnas.96.8.4552
发表时间：
1999-04-13
影响因子：
11.1
作者：
Martin, DA;Zheng, LX;Lenardo, MJ
通讯作者：
Lenardo, MJ
影响因子：
12.4
作者：
Ouasti, S.;Matarrese, P.;Degli Esposti, M.
通讯作者：
Degli Esposti, M.