Baseline knee adduction and flexion moments during walking are both associated with 5 year cartilage changes in patients with medial knee osteoarthritis.
Baseline knee adduction and flexion moments during walking are both associated with 5 year cartilage changes in patients with medial knee osteoarthritis.
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DOI：
10.1016/j.joca.2014.08.009
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发表时间：
2014-11
影响因子：
7
通讯作者：
Andriacchi, T. P.
中科院分区：
文献类型：
--
作者：
Chehab, E. F.;Favre, J.;Erhart-Hledik, J. C.;Andriacchi, T. P.
检验膝关节软骨在5年内的变化与早期站立时的基线峰值膝关节内收力矩（KAM）和峰值膝关节屈曲力矩（KFM）相关的假设。在16名内侧膝关节OA受试者中测量基线KAM和KFM。在基线和五年后再次使用磁共振成像量化软骨厚度的区域变化和内外侧厚度比的变化。多元回归用于确定KAM和KFM的基线测量值是否与五年内的软骨变化相关。在KAM和KFM存在的情况下，逐一测试与基线疼痛评分、Kelling-Lawrence分级、步行速度、年龄、性别和体重指数的相关性。5年内股骨内外侧厚度比的变化与基线KAM、KFM和疼痛评分相关（R2=0.60，p=0.010），与KAM相关性最显著（R2=0.33，p=0.019）。胫骨内外侧厚度比的变化与基线KAM、KFM和步行速度相关（R2=0.49，p=0.039），KFM驱动了这种关联（R2=0.40，p=0.009）。胫骨内侧厚度的变化与基线KAM、KFM和步行速度相关（R2=0.49，p=0.041）; KFM也驱动了这种关联（R2=0.42，p=0.006）。KAM对股骨软骨变化有更大的影响，KFM对胫骨软骨变化有更大的影响，这一发现为与行走动力学相关的软骨变化中的胫股变化提供了新的见解。这些结果表明，KAM和KFM应考虑在设计疾病干预措施，以及评估OA进展的风险。
To test the hypothesis that knee cartilage changes over five years are associated with baseline peak knee adduction moment (KAM) and peak knee flexion moment (KFM) during early stance. Baseline KAM and KFM were measured in sixteen subjects with medial knee OA. Regional changes in cartilage thickness and changes in medial-to-lateral thickness ratio were quantified using magnetic resonance imaging at baseline and again after five years. Multiple regression was used to determine whether baseline measures of KAM and KFM were associated with cartilage changes over five years. Associations with baseline pain score, Kellgren-Lawrence grade, walking speed, age, gender, and body mass index were tested one-by-one in the presence of KAM and KFM. Changes over five years in femoral medial-to-lateral thickness ratio were associated with baseline KAM, KFM, and pain score (R2=0.60, p=0.010), and most significantly with KAM (R2=0.33, p=0.019). Changes in tibial medial-to-lateral thickness ratio were associated with baseline KAM, KFM, and walking speed (R2=0.49, p=0.039), with KFM driving this association (R2=0.40, p=0.009). Changes in medial tibial thickness were associated with baseline KAM, KFM, and walking speed (R2=0.49, p=0.041); KFM also drove this association (R2=0.42, p=0.006). The findings that the KAM has a greater influence on femoral cartilage change and the KFM has a greater influence on tibial cartilage change provide new insight into the tibiofemoral variations in cartilage changes associated with walking kinetics. These results suggest that both KAM and KFM should be considered when designing disease interventions as well as when assessing the risk for OA progression.
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影响因子：
7
作者：
Baliunas, AJ;Hurwitz, DE;Andriacchi, TP
通讯作者：
Andriacchi, TP
DOI：
10.2106/00004623-197658060-00003
发表时间：
1976-01-01
影响因子：
5.3
作者：
INSALL, JN;RANAWAT, CS;SHINE, J
通讯作者：
SHINE, J
影响因子：
2.4
作者：
Kaufman, KR;Hughes, C;An, KN
通讯作者：
An, KN
影响因子：
27.4
作者：
Cicuttini, FM;Wluka, A;Stuckey, SL
通讯作者：
Stuckey, SL
影响因子：
2.8
作者：
Hurwitz, DE;Ryals, AR;Andriacchi, TP
通讯作者：
Andriacchi, TP