Ribosome-based quality control of mRNA and nascent peptides.
Ribosome-based quality control of mRNA and nascent peptides.
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DOI：
10.1002/wrna.1366
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发表时间：
2017-01
影响因子：
7.3
通讯作者：
Zaher, Hani S.
中科院分区：
文献类型：
--
作者：
Simms, Carrie L.;Thomas, Erica N.;Zaher, Hani S.
质量控制过程是普遍的，并在检测有缺陷的分子和去除它们以保持生物体的健康方面发挥着重要作用。异常的mRNA分子，除非得到适当的管理，对细胞蛋白质稳定构成重大障碍。通常mRNA具有提前终止密码子，具有呈现对翻译机制的阻断的结构，或完全缺乏终止密码子。在真核生物中，三种细胞质mRNA监视过程，无义介导的衰变（NMD），不去衰变（NGD）和不停止衰变（NSD），分别进化以科普这些异常的mRNA。非终止mRNA和抑制翻译延伸的mRNA尤其成问题，因为它们从翻译核糖体库中隔离有价值的核糖体。因此，除了RNA降解，NSD和NGD在生命的所有领域都与核糖体拯救密切相关。此外，由所有三类缺陷mRNA产生的蛋白质产物更容易发生故障。因此，这些截短的新生蛋白质产物发生降解并不奇怪。在过去的几年里，许多研究已经开始记录核糖体在启动RNA和蛋白质质量控制过程中的核心作用。核糖体似乎负责识别靶mRNA，以及募集进行核糖体拯救和新生蛋白质降解过程所需的因子。
Quality control processes are widespread and play essential roles in detecting defective molecules and removing them in order to maintain organismal fitness. Aberrant mRNA molecules, unless properly managed, pose a significant hurdle to cellular proteostasis. Often mRNAs harbor premature stop codons, possess structures that present a block to the translational machinery, or lack stop codons entirely. In eukaryotes, the three cytoplasmic mRNA-surveillance processes, nonsense-mediated decay (NMD), no-go decay (NGD) and non-stop decay (NSD), evolved to cope with these aberrant mRNAs, respectively. Non-stop mRNAs and mRNAs that inhibit translation elongation are especially problematic as they sequester valuable ribosomes from the translating ribosome pool. As a result, in addition to RNA degradation, NSD and NGD are intimately coupled to ribosome rescue in all domains of life. Furthermore, protein products produced from all three classes of defective mRNAs are more likely to malfunction. It is not surprising then that these truncated nascent protein products are subject to degradation. Over the past few years, many studies have begun to document a central role for the ribosome in initiating the RNA and protein quality control processes. The ribosome appears to be responsible for recognizing the target mRNAs, as well as for recruiting the factors required to carry out the processes of ribosome rescue and nascent protein decay.
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影响因子：
7.2
作者：
Dever TE;Green R
通讯作者：
Green R
DOI：
10.1073/pnas.0812819106
发表时间：
2009-02-17
影响因子：
11.1
作者：
Chu, Jessie;Hong, Nancy A.;Kay, Steve A.
通讯作者：
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影响因子：
4.8
作者：
Dimitrova, Lyudmila N.;Kuroha, Kazushige;Inada, Toshifumi
通讯作者：
Inada, Toshifumi
影响因子：
64.8
作者：
Amrani, N;Ganesan, R;Jacobson, A
通讯作者：
Jacobson, A
影响因子：
64.5
作者：
Alkalaeva, Elena Z.;Pisarev, Andrey V.;Pestova, Tatyana V.
通讯作者：
Pestova, Tatyana V.