Secondary neoplasms following treatment for brain tumors.

Secondary neoplasms following treatment for brain tumors.
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脑肿瘤治疗后的继发性肿瘤。

DOI:
10.1007/b109924_16
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发表时间:
2009
影响因子:
--
通讯作者:
M. Watral
M. Watral
中科院分区:
--
文献类型:
--
作者:
J. Weinstein;K. Ayyanar;M. Watral

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继发性恶性肿瘤(SMN)被认为是癌症治疗最具破坏性的晚期效应之一,因为它们与显着的发病率和死亡率相关。 SMN 被定义为首次癌症后出现的组织学上不同的肿瘤,估计占美国所有癌症诊断的 6-10%。 1, 2 特别是,在儿童期和青春期有癌症病史的幸存者患 SMN 的风险显着增加。治疗方法的进步提高了这些儿科患者的生存率,但导致发生其他肿瘤的风险增加了 5-10 倍。 3-16 此外,随着生存率不断提高,预计 SMN 的发生率也会相应增加。 9, 15, 17–24
Secondary malignant neoplasms (SMNs) are considered one of the most devastating late effects of cancer therapies, as they are associated with significant morbidity and mortality. Defined as histologically distinct neoplasms that develop after a first cancer, SMNs are estimated to account for 6–10% of all cancer diagnoses in the United States. 1, 2 In particular, survivors with a history of cancers during childhood and adolescence have a significantly increased risk of developing a SMN. The therapeutic advances that have improved survival in these pediatric patients have resulted in a 5–10-fold increased risk of developing additional tumors. 3–16 Additionally, as survival rates continue to improve, it is predicted that the occurrence of SMN will increase accordingly. 9, 15, 17–24
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DOI: 10.1210/jcem.85.9.6808
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影响因子: --
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