Diverse roles of C-terminal Hsp70-interacting protein (CHIP) in tumorigenesis
Diverse roles of C-terminal Hsp70-interacting protein (CHIP) in tumorigenesis
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C 端 Hsp70 相互作用蛋白 (CHIP) 在肿瘤发生中的多种作用
DOI：
10.1007/s00432-013-1571-5
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发表时间：
2014-02
影响因子：
3.6
通讯作者：
Zheng, Jun-Nian
中科院分区：
文献类型：
--
作者：
Shi, Mei-Lin;Liu, Qing-Hua;Bai, Jin;Zheng, Jun-Nian
研究背景热休克蛋白70相互作用蛋白（CHIP）的羧基端是E3泛素连接酶的一个成员，是连接分子伴侣（热休克蛋白70/90）和蛋白酶体系统的纽带，在维持细胞质内蛋白质稳态中起重要作用。CHIP已被证明参与多种恶性肿瘤的发生、增殖和侵袭，调节许多致癌蛋白。然而，CHIP也涉及肿瘤抑制蛋白的调节。CHIP在人类恶性肿瘤中表达的致病机制尚不清楚，许多研究表明CHIP在不同癌症中可能具有相反的作用。结果与结论CHIP可能是一种潜在的肿瘤诊断标志物和治疗靶点，在不同的肿瘤中可能发挥不同的作用。这种不一致性可能是由CHIP下游靶向蛋白的多样性引起的。因此，CHIP确定的表型应取决于其特定靶点在特定类型癌细胞中的功能。CHIP是否有助于各种人类癌症的肿瘤进展或抑制仍不清楚，这表明有必要进一步广泛研究其在肿瘤发生中的作用。
BackgroundThe carboxyl terminus of Hsp70-interacting protein (CHIP) is a member of E3 ubiquitin ligase, functioning as a link between the chaperone (heat shock protein 70/90) and proteasome systems, playing a vital role in maintaining the protein homeostasis in the cytoplasm. CHIP has been demonstrated to be involved in tumorigenesis, proliferation and invasion in several malignancies, regulating a number of oncogenic proteins. However, CHIP has also been implicated in the modulation of tumor suppressor proteins. The pathogenic mechanism of CHIP expression in human malignancy is not yet clear, and a number of studies have suggested that CHIP may have opposing roles in different cancers. Therefore, many studies have focused on the relationship between CHIP and carcinoma.MethodsA literature search focusing on regulation network, biological function and clinical significance of CHIP in connection with its role in cancer development was performed on the MEDLINE databases.Results and conclusionsCHIP may be a potential diagnostic biomarker and therapeutic target for human cancer, and may play different roles in different human cancers. This inconsistence might be induced by the diversity of CHIP downstream targeting proteins. Therefore, the phenotypes determined by CHIP should be dependent on the function of its specific targets in a specific type of cancer cells. Whether CHIP contributes to tumor progression or suppression in various human cancers remains unclear, suggesting the necessity of further extensive investigation of its role in tumorigenesis.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
2.9
作者：
Liang ZL;Kim M;Huang SM;Lee HJ;Kim JM
通讯作者：
Kim JM
CHIP缺失揭示了E3连接酶在促进信号蛋白和扩展的谷氨酰胺蛋白的降解方面的功能冗余。
影响因子：
3.5
作者：
Morishima Y;Wang AM;Yu Z;Pratt WB;Osawa Y;Lieberman AP
通讯作者：
Lieberman AP
CHIP 促进 Runx2 降解并负向调节成骨细胞分化
影响因子：
7.8
作者：
Li, Xueni;Huang, Mei;Zheng, Huiling;Wang, Yinyin;Ren, Fangli;Shang, Yu;Zhai, Yonggong;Irwin, David M.;Shi, Yuguang;Chen, Di;Chang, Zhijie
通讯作者：
Chang, Zhijie
影响因子：
5.7
作者：
Lianne Fuino;P. Bali;S. Wittmann;S. Donapaty;F. Guo;H. Yamaguchi;Hong-Gang Wang;P. Atadja;K. B
通讯作者：
Lianne Fuino;P. Bali;S. Wittmann;S. Donapaty;F. Guo;H. Yamaguchi;Hong-Gang Wang;P. Atadja;K. B