Expression of carboxyl terminus of Hsp70-interacting protein (CHIP) indicates poor prognosis in human gallbladder carcinoma.
Expression of carboxyl terminus of Hsp70-interacting protein (CHIP) indicates poor prognosis in human gallbladder carcinoma.
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DOI：
10.3892/ol.2013.1138
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发表时间：
2013-03
期刊：
影响因子：
2.9
通讯作者：
Kim JM
中科院分区：
文献类型：
--
作者：
Liang ZL;Kim M;Huang SM;Lee HJ;Kim JM
胆囊癌（GBC）是一种致死性肿瘤，需要新的预后标志物。E3连接酶的失调有助于癌症的发展，并与预后不良有关。热休克蛋白70相互作用蛋白（CHIP）的羧基末端是一种U盒型E3泛素连接酶，其在胆囊癌中的作用尚未被评估。因此，本研究探讨了CHIP在GBC中的表达及其预后意义。本研究采用免疫组化方法检测78例胆囊癌组织中CHIP的表达，并分析其与临床病理因素的关系。在肿瘤标本中，26.9%显示高染色强度[CHIP高表达组（HEG）]。CHIP-HEG与T分期、淋巴结转移、远处转移等临床病理参数无相关性。CHIP-HEG患者的预后显著差于CHIP低表达患者，中位癌症特异性生存时间分别为8.0个月（范围，1-34个月）和13.0个月（范围，1-110个月）（P=0.023）。多变量分析显示，CHIP表达接近于成为预测患者生存的独立风险因素。CHIP表达可能与GBC的不良预后相关。由于CHIP与其他临床病理预后因素无关，因此它可能作为预测患者预后的理想分子标志物。
Gallbladder carcinoma (GBC) is a lethal neoplasm, and new prognostic markers are required. Deregulation of E3 ligases contributes to cancer development and is associated with poor prognosis. Carboxyl terminus of heat shock protein 70-interacting protein (CHIP) is a U-box-type E3 ubiquitin ligase, the role of which has not been evaluated in GBC. Therefore, the present study investigated CHIP expression in GBC and its prognostic significance. In the present study, CHIP expression was measured in 78 tumor specimens of GBC by immunohistochemistry and the correlation between CHIP expression and clinicopathological factors was analyzed. Of the tumor specimens, 26.9% showed high staining intensity [the CHIP high expression group (HEG)]. The CHIP-HEG was not associated with other common clinicopathological parameters, including T stage, and lymph node and distant metastases. CHIP-HEG patients had a significantly worse prognosis than patients with low CHIP expression with median cancer-specific survival times of 8.0 months (range, 1–34 months) and 13.0 months (range, 1–110 months), respectively (P=0.023). Multivariate analyses showed that CHIP expression was close to being an independent risk factor for predicting patient survival. CHIP expression may be associated with a poor prognosis in GBC. Since CHIP is not associated with other clinicopathological prognostic factors, it may serve as an ideal molecular marker for predicting patient outcomes.
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影响因子：
21.3
作者：
Connell, P;Ballinger, CA;Patterson, C
通讯作者：
Patterson, C
影响因子：
21.3
作者：
Kajiro, Masashi;Hirota, Ryuichi;Yanagisawa, Junn
通讯作者：
Yanagisawa, Junn
影响因子：
2.5
作者：
Giatromanolaki, A.;Sivridis, E.;Koukourakis, M. I.
通讯作者：
Koukourakis, M. I.
影响因子：
3.2
作者：
Choi, YL;Xuan, YH;Kim, SH
通讯作者：
Kim, SH
影响因子：
64.8
作者：
Haupt, Y;Maya, R;Oren, M
通讯作者：
Oren, M