Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration.
Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration.
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DOI：
10.3389/fimmu.2021.589095
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发表时间：
2021
影响因子：
7.3
通讯作者：
Zhang P
中科院分区：
文献类型：
--
作者：
Chen R;Lan Z;Ye J;Pang L;Liu Y;Wu W;Qin X;Guo Y;Zhang P
由新型严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）大流行是对全球健康的持续重大威胁，并对COVID-19重症患者的治疗提出了重大挑战。多项研究报告称，细胞因子风暴是COVID-19患者疾病恶化和死亡的重要原因。因此，了解细胞因子风暴如何促进COVID-19恶化的特定病理生理过程非常重要。在这里，我们概述了细胞因子风暴导致SARS-CoV-2感染恶化的病理生理过程，并描述了SARS-CoV-2和免疫系统之间的相互作用，以及导致急性呼吸窘迫综合征（ARDS），多器官功能障碍综合征（MODS）和凝血功能障碍的免疫反应功能障碍的病理生理学。还描述了基于抑制细胞因子风暴诱导的恶化和发生的治疗。
The coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing major threat to global health and has posed significant challenges for the treatment of severely ill COVID-19 patients. Several studies have reported that cytokine storms are an important cause of disease deterioration and death in COVID-19 patients. Consequently, it is important to understand the specific pathophysiological processes underlying how cytokine storms promote the deterioration of COVID-19. Here, we outline the pathophysiological processes through which cytokine storms contribute to the deterioration of SARS-CoV-2 infection and describe the interaction between SARS-CoV-2 and the immune system, as well as the pathophysiology of immune response dysfunction that leads to acute respiratory distress syndrome (ARDS), multi-organ dysfunction syndrome (MODS), and coagulation impairment. Treatments based on inhibiting cytokine storm-induced deterioration and occurrence are also described.
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DOI：
10.1016/j.biopha.2021.111330
发表时间：
2021-05
期刊：
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
影响因子：
--
作者：
Awadasseid A;Wu Y;Tanaka Y;Zhang W
通讯作者：
Zhang W
影响因子：
64.5
作者：
Aid M;Busman-Sahay K;Vidal SJ;Maliga Z;Bondoc S;Starke C;Terry M;Jacobson CA;Wrijil L;Ducat S;Brook OR;Miller AD;Porto M;Pellegrini KL;Pino M;Hoang TN;Chandrashekar A;Patel S;Stephenson K;Bosinger SE;Andersen H;Lewis MG;Hecht JL;Sorger PK;Martinot AJ;Estes JD;Barouch DH
通讯作者：
Barouch DH
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
5.7
作者：
Levi, Marcel;Nieuwdorp, Max;Stroes, Erik
通讯作者：
Stroes, Erik
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny