Proteinase Inhibitor Gene Families: Tissue Specificity and Regulation
Proteinase Inhibitor Gene Families: Tissue Specificity and Regulation
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蛋白酶抑制剂基因家族：组织特异性和调控
DOI：
10.1007/978-3-7091-6950-6_12
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发表时间：
1988
影响因子：
6.4
通讯作者：
C. Ryan
中科院分区：
文献类型：
--
作者：
C. Ryan
蛋白酶抑制剂是自然界中普遍存在的多家族蛋白质（Laskowski，Jr.和Kato，1984年）。已经分离出特异性抑制四种已知机制的蛋白水解酶中的每一种的抑制蛋白，即：e.丝氨酸、巯基、乙酰基和金属蛋白酶。总的来说，丝氨酸蛋白酶抑制剂包含超过十个不相关的蛋白质家族（Laskowski，Jr.，1986年），发现在动物和植物王国（表1）。这些抑制剂蛋白的功能作用似乎是保护组织或体液免受外来蛋白酶的蛋白水解，或调节与它们相关的组织或体液中具有代谢活性的蛋白酶的水平。已经从植物中纯化的大多数蛋白酶抑制剂蛋白是丝氨酸内肽酶的抑制剂，例如动物消化酶胰蛋白酶、胰凝乳蛋白酶和弹性蛋白酶或细菌蛋白酶枯草杆菌蛋白酶。在植物中，抑制剂蛋白通常占各种贮藏器官如种子和块茎的蛋白的1 - 15%或更多（Ryan，1974），并且在一些植物物种中，在叶中，在果实中，或在两者中（见下文）。
Proteinase inhibtors are a multifamily group of proteins that are ubiquitous in nature (Laskowski, Jr. and Kato, 1984). Inhibitor proteins have been isolated that specifically inhibit each of the four known mechanistic classes of proteolytic enzymes, i. e. serine, thiol, aspartyl and metalloproteinases. Overall, the serine proteinase inhibitors comprise over ten unrelated protein families (Laskowski, Jr., 1986) that are found within the animal and plant kingdoms (Table 1). The functional role of these inhibitor proteins appears to be either to protect tissues or fluids from proteolysis by foreign proteases or to regulate the levels of proteases that are metabolically active in the tissues or fluids that they are associated with. The majority of proteinase inhibitor proteins that have been purified from plants have been inhibitors of serine endopeptidases such as the animal digestive enzymes trypsin, chymotrypsin and elastase or the bacterial proteinase subtilisin. In plants, the inhibitor proteins usually account for from 1 – 15 % or more of the proteins of various storage organs such as seeds and tubers (Ryan, 1974) and in some plant species, in leaves, in fruit, or in both (see below).
DOI：
10.1073/pnas.83.19.7277
发表时间：
1986-10-01
影响因子：
11.1
作者：
LEE, JS;BROWN, WE;RYAN, CA
通讯作者：
RYAN, CA